yichen.jpg

email.jpg

yjchen@dragon.nchu.edu.tw

yjc.jpg

有機化學

Organic Chemistry

 

R.jpg

1.          B. S., National Chung Hsing University (1977)

2.          Ph. D., Ohio State University (1986)

3.          Teaching Assistent, National Chung Hsing University (1979-1981)

4.          Associate Professor, Providence University (1986-1988)

5.          Associate Professor, National Chung Hsing University (1988-1994)

6.          Professor, National Chung Hsing University (1994-)

7.          Chairman, Dept. of Chemistry, National Chung Hsing University (2000-2003)

RI_C.jpg

本實驗室主要研究方向包含開發新的反應及合成方法與其應用之研究,並研究其反應機構。而近年來主要著重於如何利用銅催化偶合反應以建立碳-氮、碳-硫、及碳-氧等化學鍵之研究,並應用此方法於合成有機染料、光電材料、或藥物分子。目前已知方法常困擾於需高溫反應,或缺乏對反應物種的通用性等問題。最主要是常因不同種類反應就需特殊配位基和銅組成之催化系統方能進行。當然更值得注意的是,這些特殊配位基常是價格昂貴,或是需較繁瑣步驟自行合成。因此基於改善上述之缺點,開發多樣性的且便宜的新螯合配位基和銅組成新催化系統是重要且具挑戰的。例如,本實驗室已成功開發利用新戊烷三醇和銅組成新催化系統,對醯氨及含氮雜環化合物進行苯基化反應可以得到很高產率的產物。更重要的是,新戊烷三醇可以便宜購買得到,且具多樣性的反應型態,可輕易建立碳-氮、碳-硫、碳-氧等化學鍵。開發更多的新螯合配位基,及應用這些方法於有機分子合成,是本實驗室未來主要的研究目標。

RI.jpg

The mainly interesting topics in our researches involve the development of new methodologies for the functionality transformation of interesting and useful organic molecules as well as their mechanistic studies.  Recently, we have been interested in the development of new, less costly, and versatile ligands in the copper- catalyzed formation of C-N, C-S, and C-O bonds. For example, we have found that 1,1,1-tris (hydroxymethyl) ethane can be used as a new, efficient, and versatile tridentate ligand in the copper-catalyzed cross-coupling reactions of aryl iodides with amides, azaheterocycles, thiols, and phenols to afford the correspondingly desired products in good to excellent yields.  However, we are interested not only in developing new methodologies but also in synthesizing some useful dyes and bioactive materials by using our new protocols.

SP.jpg

1.      Y.-J. Chen and H.-H. Chen, 1,1,1-Tris(hydroxymethyl)ethane as a New, Efficient, and Versatile Tripod Ligand for Copper-Catalyzed Cross-Coupling Reactions of Aryl Iodides with Amides, Thiols, and Phenols, Org. Lett., 2006, 8, 5609.

2.      Y.-J. Chen and J.-Y. Shen, Activation of superoxide by boron trifluoride:chemoselective and efficient oxidation of sulfides to sulfoxides via tetrafluorodiboronperoxide, Tetrahedron Lett., 2005, 46, 4205.

3.      Y.-J. Chen, and J.-M. Zen, Process for Electrochemical Decomposition of Organic Pollutants, 2003, EP 0876831B1.

4.      Y.-J. Chen and Y.-P. Huang, Chemoselective and efficient oxidation of sulfides to sulfoxides mediated by trimethylsilyl chloride and superoxide via a trimethylsilylperoxy radical, Tetrahedron Lett., 2000, 41, 5233.

5.      Y.-J. Chen and W.-H. Chang, Stereocontrolled Tandem Radical Cyclization: A New and Facile Route to Syntheses of (+)-α-Biotol and (+)-α-Biotol, J. Org. Chem., 1996, 61, 2536.

6.      Y.-J. Chen, C.-Y. Wang and W.-Y. Lin, Radical Cyclization of a-Allenic Ketone: A New Approach to the Synthesis of (+)-α-Chamigrene, Tetrahedron, 1996, 52, 13181.

7.      Y.-J. Chen, C.-M. Chen and W.-Y. Lin, A New Approach To The Formal Synthesis Of (+)-α-Cedrene, Tetrahedron Lett., 1993, 34, 2961.

8.      Y.-J. Chen, W.-Y. Lin, A Facile Synthesis Of A Δ2-Cedrene Skeloton Via Tandem Radical Cyclization, Tetrahedron Lett., 1992, 33 , 1749.

國立中興大學化學系National Chung Hsing University Department of Chemistry

地址:台中市國光路250號 化學館 電話:04-22840411 傳真:04-22862547