Organic Chemistry



1.          B. S., National Chung Hsing University (1977)

2.          Ph. D., Ohio State University (1986)

3.          Teaching Assistent, National Chung Hsing University (1979-1981)

4.          Associate Professor, Providence University (1986-1988)

5.          Associate Professor, National Chung Hsing University (1988-1994)

6.          Professor, National Chung Hsing University (1994-)

7.          Chairman, Dept. of Chemistry, National Chung Hsing University (2000-2003)




The mainly interesting topics in our researches involve the development of new methodologies for the functionality transformation of interesting and useful organic molecules as well as their mechanistic studies.  Recently, we have been interested in the development of new, less costly, and versatile ligands in the copper- catalyzed formation of C-N, C-S, and C-O bonds. For example, we have found that 1,1,1-tris (hydroxymethyl) ethane can be used as a new, efficient, and versatile tridentate ligand in the copper-catalyzed cross-coupling reactions of aryl iodides with amides, azaheterocycles, thiols, and phenols to afford the correspondingly desired products in good to excellent yields.  However, we are interested not only in developing new methodologies but also in synthesizing some useful dyes and bioactive materials by using our new protocols.


1.      Y.-J. Chen and H.-H. Chen, 1,1,1-Tris(hydroxymethyl)ethane as a New, Efficient, and Versatile Tripod Ligand for Copper-Catalyzed Cross-Coupling Reactions of Aryl Iodides with Amides, Thiols, and Phenols, Org. Lett., 2006, 8, 5609.

2.      Y.-J. Chen and J.-Y. Shen, Activation of superoxide by boron trifluoride:chemoselective and efficient oxidation of sulfides to sulfoxides via tetrafluorodiboronperoxide, Tetrahedron Lett., 2005, 46, 4205.

3.      Y.-J. Chen, and J.-M. Zen, Process for Electrochemical Decomposition of Organic Pollutants, 2003, EP 0876831B1.

4.      Y.-J. Chen and Y.-P. Huang, Chemoselective and efficient oxidation of sulfides to sulfoxides mediated by trimethylsilyl chloride and superoxide via a trimethylsilylperoxy radical, Tetrahedron Lett., 2000, 41, 5233.

5.      Y.-J. Chen and W.-H. Chang, Stereocontrolled Tandem Radical Cyclization: A New and Facile Route to Syntheses of (+)-α-Biotol and (+)-α-Biotol, J. Org. Chem., 1996, 61, 2536.

6.      Y.-J. Chen, C.-Y. Wang and W.-Y. Lin, Radical Cyclization of a-Allenic Ketone: A New Approach to the Synthesis of (+)-α-Chamigrene, Tetrahedron, 1996, 52, 13181.

7.      Y.-J. Chen, C.-M. Chen and W.-Y. Lin, A New Approach To The Formal Synthesis Of (+)-α-Cedrene, Tetrahedron Lett., 1993, 34, 2961.

8.      Y.-J. Chen, W.-Y. Lin, A Facile Synthesis Of A Δ2-Cedrene Skeloton Via Tandem Radical Cyclization, Tetrahedron Lett., 1992, 33 , 1749.

國立中興大學化學系National Chung Hsing University Department of Chemistry

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