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gilin@dragon.nchu.edu.tw

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生物化學

Biochemistry

 

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1.          B. S., National Taiwan University (1982)

2.          Ph. D., Department of Chemistry, The Ohio State University (1989)

3.          Postdoctor, Department of Chemistry, University of Iowa (1989-1990)

4.          Research Associate, Department of Radiology, University of Pennsylvania (1990-1991)

5.          Associate Professor, National Chung Hsing University (1991)

6.          Professor, National Chung Hsing University (1999-)

7.          Visiting Scholar, Genomics Research Center, Academia Sinica (2006-2007)

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本實驗室主要研究是酵素抑制與脂肪的物理化學。我們定量結構分析原理對與下列藥物設計(1)治療老人失智症之乙醯膽鹼酯酵素抑制劑，(2)抗青黴素活性之青黴素酵素抑制劑，(3)降低膽固醇之膽固醇酯酵素抑制劑，(4)抗凝血之凝血酵素抑制劑，(5) 磷脂酵素A2抑制劑之非類固醇抗發炎藥(NSAID)，及(6) 減重之脂肪酵素抑制劑之探討。。我們也有興趣利用NMR及其它方法研究脂肪的結構。

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Our research interests focus on both enzyme inhibition and physical chemistry of lipids.  We are interested in the development of new drugs by quantitative structure activity relationship (QSAR) for (1) treatment of Alzheimer’s disease based on acetylcholinesterase inhibitors, (2) anti-penicillinase activity from the penicillinase inhibitors, (3) lowering cholesterol ester level from cholesterol esterase inhibitors, (4) anticoagulant from Thrombin inhibitors, (5) NSAID for phospholipase A2 inhibitor, and (6) weight control based on the inhibitor of lipase.  We are also interested in elucidation of lipid structures by NMR.

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A. 期刊論文 (Publications) (red: IF>2, blue: 1<IF<2, black: 0<IF<1, green: not SCI)

1.      Shyh-Ying Chiou, Gia-Yun Yu, Gialih Lin*, “QSAR for Inhibition of Pseudomonas Species Lipase by 1-Acyloxy-3-N-n-octylcarbamyl-benzenes”, QSAR & Combinatorial Science, 2009, 28, 267-273.

2.      Shyh-Ying Chiou, Yu-Ru Chen, Chun-Ping Lu, Long-Yau Lin, and Gialih Lin*, “The conformational freeze for the ethylene glycol backbone of 1,2-ethylene-di-N-n-propylcarbamate in triton X-100 mixed micelle”, Journal Physical Chemistry C, 2008, 112, 2325-2329.

3.      Ming-Cheng Lin, Gin-Win Lai, Chung-Sheng Lin, and Gialih Lin.* Activation Mechanisms for Pseudomonas Species Lipase by Cardiovascular Drugs in Vitro. Journal of the Chinese Chemical Society, 2007, in press. NSC 95-2113-M005-006-MY2, SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

4.      Ming-Cheng Lin, Mei-Ting, Han-Gin Chang, Chung-Sheng Lin, and Gialih Lin.* Benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates as conformationally constrained of inhibitors of acetylcholinesterase. Journal of Biochemical and Molecular Toxicology, 2007, in press (NSC 95-2113-M005-006-MY2), SCI impact factor 1.418, 199/262 (biochemistry & molecular biology), 51/76 (toxicology), corresponding author.

5.      Ming-Cheng Lin, Mei-Ting, Han-Gin Chang, Chung-Sheng Lin, and Gialih Lin.*  Benzene-di-N-substituted-carbamates as Conformationally constrained analogs of lipase substrate. European Journal of Lipid Science and Technology, 2007, in press. (NSC 95-2113-M005-006-MY2), SCI impact factor 1.184, 31/96 (food science & technology), corresponding author.

6.      Ming-Cheng Lin, Chi-Wei Hsieh, Hou-Jen Tsai, Yu-Ru Ro, Chung-Sheng Lin, and Gialih Lin.* Interaction Mechanism between Pseudomonas Species Lipase and Nitro Compounds. Asian Journal of Chemistry, 2007, in press. (NSC 95-2113-M005-006-MY2), SCI impact factor 0.173, 121/124 (chemistry, multidisciplinary), corresponding author.

7.      Shyh-Ying Chiou, Yon-Gi Wu, Yan-Fu Lin, Long-Yau Lin, and Gialih Lin.* Substrate activation of butyrylcholinesterase and substrate inhibition of acetylcholinesterase by 3,3-dimethylbutyl-N-n-butylcarbamate and 2-trimethylsilyl-ethyl-N-n-butylcarbamate. Journal of Biochemical and Molecular Toxicology 2007, 21, 24-31 (NSC 95-2113-M005-006-MY2), SCI impact factor 1.418, 199/262 (biochemistry & molecular biology), 51/76 (toxicology), corresponding author.

8.      Ming-Cheng Lin, Chun-Ping Lu, Yu-Ru Cheng, Yan-Fu Lin, Chung-Sheng Lin, Gialih Lin.* Inhibition or activation of Pseudomonas species lipase by 1,2-ethylene-di-N-alkylcarbamates in detergents. Chemistry and Physics of Lipids, 2007, 146, 85-93. (NSC 95-2113-M005-006-MY2), SCI impact factor 2.371, 33/66 (biophysics), 138/262 (biochemistry & molecular biology), corresponding author.

9.      Gialih Lin*, Fu-Hwey Lai Bo-I Tsai, Chi-Wei Hsieh, and Hou-Jen Tsai. Probing conformations of the glycerol backbones of triacyglycerols in the active site of lipase by 1,2-cyclopentane- carbamates: the meso effect for the enzyme inhibition. Journal of Molecular Catalysis. B, Enzymatic 2006, 40, 86-92. (NSC 94-2113-M005-006), SCI impact factor 2.149, 41/108 (chemistry, physical), 150/262 (biochemistry & molecular biology), corresponding author.

10.  Shyh-Ying Chiou, Gin-Win Lai, Long-Yau Lin, and Gialih Lin.* Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro. Indian Journal of Biochemistry and Biophysics, 2006, 43, 52-55. (NSC 94-2113-M005-006), SCI impact factor 0.277, 255/262 (biochemistry & molecular biology), corresponding author.

11.  Shyh-Ying Chiou, Yu-Ru Cheng, Chun-Ping Lu, Yan-Fu Lin, Long-Yau Lin, and Gialih Lin.* Kinetics and quantitative structure activity relationships for Pseudomonas species lipase catalyzed hydrolysis of both monoesters and diesters of ethylene glycol. Journal of the American Oil Chemists’ Society, 2006, 83, 201-207. (NSC 94-2113-M005-006), SCI impact factor 0.910, 26/58 (chemistry, applied), 45/96 (food science & technology), corresponding author.

12.  Gialih Lin,* Shyh-Ying Chiou, Bi-Chiang Hwu, and Chi-Wei Hsieh. Probing structure-function relationships of serine hydrolases and proteases with carbamate and thiocarbamate inhibitors. Protein Journal, 2006, 25, 33-43. (NSC 94-2113-M005-006), SCI impact factor 0.962, 221/262 (biochemistry & molecular biology), corresponding author.

13.  Shyh-Ying Chiou, Gin-Win Lai, Yi-Hon Tsai, Long-Yau Lin, and Gialih Lin.* QSAR for acetylcholinesterase and butyrylcholinesterase inhibition by cardiovascular drugs and benzodiazepines. Medicinal Chemistry Research 2005, 14, 297-308. (NSC 94-2113-M005-006), SCI impact factor 0.225, 35/35 (chemistry, medicinal), corresponding author.

14.  Shyh-Ying Chiou, Cheng-Yue Lai, Long-Yau Lin, Gialih Lin.* Probing stereoselective inhibition of the acyl binding site of cholesterol esterase with four diastereomers of 2’-N-apha-methylbenzylcarbamyl-1,1’-bi-2-naphthol. BMC Biochemistry 2005, 6 (17), 1-9. (NSC 93-2113-M005-012), unofficial SCI impact factor 2.04, corresponding author.

15.  Gialih Lin,* Yu-Ru Lee, Yu-Chen Liu, and Yon-Gi Wu. Ortho effects for inhibition mechanisms of butyrylcholinesterase by o-substituted phenyl N-butylcarbamates and comparison with acetylcholinesterase, cholesterol esterase, and lipase. Chemical Research in Toxicology 2005, 18, 1124-1131. (NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 3.162, 10/76 (toxicology), 23/124 (chemistry, multidisciplinary), 8/35 (chemistry, medicinal), corresponding author.

16.  Shyh-Ying Chiou, Gin-Win Lai, Yi-Hon Tsai,Yu-Ru Lee, Long-Yau Lin, and Gialih Lin.* Kinetics and mechanisms of acetylcholinesterase and butyrylcholinesterase inhibition by cardiovascular drugs and benzodiazepines. Journal of the Chinese Chemical Society 2005, 52, 843-848. (NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

17.  Gialih Lin,* Gan-Hong Chen, Chun-Ping Lu, and Shih-Chieh Yeh. QSARs for peripheral anionic site of butyrylcholinesterase with inhibitions by 4-acyloxy-biphenyl-4’-N-butylcarbamates. QSAR & Combinatorial Science 2005, 24, 943-952. (NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 1.987, 33/124 (chemistry, multidisciplinary) or 16/35 (chemistry, medicinal), corresponding author.

18.  Gialih Lin,* Gan-Hong Chen, Shih-Chieh Yeh, and Chun-Ping Lu. Probing the peripheral anionic site of acetylcholinesterase with quantitative structure activity relationships for the inhibitions by biphenyl-4-acyoxylate-4’-N-butylcarbamates. Journal of Biochemical and Molecular Toxicology 2005, 19, 234-243 (NSC 90-2113-M005-015, NSC 91-2113-M005-007, and NSC 92 2113-M005-021), SCI impact factor 1.418, 199/262 (biochemistry & molecular biology), 51/76 (toxicology), corresponding author.

19.  Gialih Lin* and Gia-Yun Yu. QSAR for Phospholipase A2 inhibitions by 1-acyloxy-3-N-n- octylcarbamylbenzenes. Bioorganic & Medicinal Chemistry Letters 2005, 15, 2405-2408.  (NSC 93-2113-M005-012), SCI impact factor 2.538, 11/35 (chemistry, medicinal) or 21/56 (chemistry, organic), corresponding author.

20.  Gialih Lin,* Wei-Cheng Liao, and Zu-Hsuan Ku. Quantitative structure-activity relationships for the pre-steady state of Pseudomonas species lipase inhibitions by p-nitrophenyl-N- substituted carbamates. Protein Journal 2005, 24, 201-207. (NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 0.962, 221/262 (biochemistry & molecular biology), corresponding author.

21.  Gialih Lin,* Hsin-Chang Tseng, Ai-Chi Chio, Tsao-Ming Tseng, and Bo-Yi Tsai. A rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by 1,n-alkane-di-N-butycarbamates. Bioorganic & Medicinal Chemistry Letters 2005, 15, 951-955. (NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 2.538, 11/35 (chemistry, medicinal) or 21/56 (chemistry, organic), corresponding author.

22.  Gialih Lin,* Gan-Hong Chen, Yan-Fu Lin, Li-Hsiang Su, and Pei-Shin Liao. Highly potent and selective 4,4’-biphenyl-4-acylate-4’-N-n-butylcarbamate inhibitors as Pseudomonas species lipase. European Journal of Lipid Science and Technology 2005, 107, 65-73. (NSC 90-2113-M005-015, NSC 91-2113-M005-007, and NSC 92 2113-M005-021) SCI impact factor 1.184, 31/96 (food science & technology), corresponding author.

23.  Gialih Lin,* Wei-Cheng Liao, Chun-Hwey Chan, Yi-Hian Wu, Hou-Jen Tsai, and Chi-Wei Hsieh. Quantitative structure-activity relationships for the pre-steady state acetylcholinesterase inhibition by carbamates. Journal of Biochemical and Molecular Toxicology 2004, 18, 353-360 (NSC 90-2113-M005-015, NSC 91-2113-M005-007, and NSC 92 2113-M005-021), SCI impact factor 1.418, 199/262 (biochemistry & molecular biology), 51/76 (toxicology), corresponding author.

24.  Gialih Lin,* Yu-Chen Liu, Yan-Fu Lin, and Yon-Gi Wu. Ortho effects in quantitative structure-activity relationships for acetylcholinesterase inhibition by aryl carbamates. Journal of Enzyme Inhibition and Medicinal Chemistry 2004, 19, 395-401 (NSC 90-2113-M005-015, NSC 91-2113-M005-007, and NSC 92 2113-M005-021) SCI impact factor 1.636, 18/35 (chemistry, medicinal) or 189/262 (biochemistry & molecular biology), corresponding author.

25.  Gialih Lin,* Yu-Chen Liu, and Yon-Gi Wu. Ortho effects and cross interaction correlations for the mechanism of cholesterol esterase inhibition by aryl carbamates. Journal of Physical Organic Chemistry 2004, 17, 707-714. (NSC 90-2113-M005-015, NSC 91-2113-M005-007, and NSC 92 2113-M005-021), SCI impact factor 1.593, 32/56 (chemistry, organic), 60/108 (chemistry, physical), corresponding author.

26.  Gialih Lin. Structure-activity relationships as probes to the inhibition mechanisms of acetylcholinesterase by aryl carbamates. II. Hammett-Taft cross-interaction correlations. Journal of the Chinese Chemical Society 2004, 51, 423-429. (NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

27.  Gialih Lin,* Yan-Fu Lin, Mei-Ting Hwang, and Yu-Zen Lin. Benzene-di-N-octylcarbamates as conformationally constrained phospholipase A2 inhibitors. Bioorganic & Medicinal Chemistry Letters 2004, 14, 751-755. (NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 2.538, 11/35 (chemistry, medicinal) or 21/56 (chemistry, organic), corresponding author.

28.  Gialih Lin,* Yue-Chen Liu, Yon-Gi Wu, and Yu-Ru Lee. Ortho effects in quantitative structure activity relationships for lipase inhibition mechanisms by aryl carbamates. QSAR & Combinatorial Science 2003, 22, 852-858. (NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 1.987, 33/124 (chemistry, multidisciplinary) or 16/35 (chemistry, medicinal), corresponding author.

29.  Gialih Lin,* Cheng-Yue Lai, Wei-Chung Liao, Pei-Shin Liao, and Chung-Hwey Chan. Structure-activity relationships as probes to the inhibition mechanisms of acetylcholinesterase by aryl carbamates. I. The steady-state kinetics. Journal of the Chinese Chemical Society 2003, 50, 1259-1265. (NSC 89-2113-M-005-036, NSC 90-2113-M005-001, NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

30.  Gialih Lin,* Hou-Jen Tsai, and Yi-Hon Tsai. Cage amines as the stopper inhibitors of cholinesterases. Bioorganic & Medicinal Chemistry Letters 2003, 13, 2887-2890. (NSC 89-2113-M-005-036, NSC 90-2113-M005-001, NSC 90-2113-M005-016, NSC 91-2113-M005-007 and NSC 92-2113-M005-021), SCI impact factor 2.538, 11/35 (chemistry, medicinal) or 21/56 (chemistry, organic), corresponding author.

31.  Gialih Lin* and Ju-Yeh Chouhwang. Quantitative structure-activity relationships for the inhibition of Pseudomonas species lipase by 4-nitrophenyl-N-substituted carbamates. Journal of Biochemistry, Molecular Biology and Biophysics 2001, 5, 301-308. (NSC 87-2113-M005-014, NSC 88-2113-M005-007 and NSC 89-2113-M005-036), SCI impact factor 1.465, 126/262 (biochemistry & molecular biology), corresponding author.

32.  Gialih Lin*, Wei-Cheng Liao, and Shyh-Ying Chiou. Quantitative structure-activity relationships for the pre-steady-state inhibition of cholesterol esterase by 4-nitrophenyl-N- substituted carbamates. Bioorganic & Medicinal Chemistry 2000, 8, 2601-2607. (NSC 87-2113-M005-014, NSC 88-2113-M005-007 and NSC 89-2113-M005-036), SCI impact factor 2.624, 10/35 (chemistry, medicinal), 20/56 (chemistry, organic), or 126/262 (biochemistry & molecular biology), corresponding author.

33.  Gialih Lin. The Hammett-Taft cross-interactions for the inhibition mechanism of cholesterol esterase by substituted phenyl-N-substituted carbamates. Journal of Physical Organic Chemistry, 2000, 13, 313-321. (NSC 87-2113-M005-014, NSC 88-2113-M005-007 and NSC 89-2113-M005-036), SCI impact factor 1.593, 32/56 (chemistry, organic), 60/108 (chemistry, physical), corresponding author.

34.  Gialih Lin*, Cheng-Yue Lai, Wei-Cheng Liao, Bing-Hong Kao, and Chun-Ping Lu. Structure-reactivity relationships as probes for the inhibition mechanism of cholesterol esterase by aryl carbamates. I. Steady-state kinetics. Journal Chinese Chemical Society 2000, 47, 489-500. (NSC 87-2113-M005-014, NSC 88-2113-M005-007 and NSC 89-2113-M005-036), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

35.  Gialih Lin*, Ching-Ing Hwang, Ju-Yueh Chouhwang, and Hou-Jen Tsai. Conformational analysis of biphenyl derivatives. I. A novel steric constant from the internal rotation of 2,2’-bis (N-substituted carbamoylmethyl)biphenyl by means of dynamic NMR. Journal Chinese Chemical Society 2000, 47, 449-454. (NSC 87-2113-M005-014, NSC 88-2113-M005-007 and NSC 89-2113-M005-036), SCI impact factor0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

36.  Gialih Lin* and Bing-Huang Kao. Epoxy type inhibitors of cholesterol esterase, acetylcholinesterase, and butyrylcholinesterase. Journal Chinese Chemical Society 2000, 47, 397-404. (NSC 87-2113-M005-014, NSC 88-2113-M005-007 and NSC 89-2113-M005-036), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

37.  Gialih Lin* and Chun-Ping Lu. Conformational analysis of 1,2-di-O-octanoyl-ethylene-glycerol during aggregation. Journal Chinese Chemical Society 2000, 47, 301-306. (NSC 87-2113-M005-014, NSC 88-2113-M005-007 and NSC 89-2113-M005-036), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

38.  林家立, 南宋官窯考, 歷史文物,2000, 10(6), 52-54. 中文, 通信作者.

39.  林家立, 是否有綠定,中國文物世界, 2000, 177, 60-61. 中文, 通信作者.

40.  Gialih Lin,* Chen-Yue Lai, and Wei-Cheng Liao. Molecular recognition by acetylcholinesterase at the peripheral anionic binding site: structure-reactivity relationships for inhibition by aryl carbamates. Bioorganic & Medicinal Chemistry 1999, 7, 2683-2689. (NSC 87-2113-M005-014 and NSC 88-2113-M005-007), SCI impact factor 2.624, 10/35 (chemistry, medicinal), 20/56 (chemistry, organic), or 126/262 (biochemistry & molecular biology), corresponding author.

41.  Gialih Lin,* Chuen-Tzwu Shieh, Hong-Chi Ho, Ju-Yueh Chouhwang, Wen-Yuan Lin, and Chun-Ping Lu. Structure-reactivity relationships for the inhibition mechanism at the second alkyl chain binding site of cholesterol esterase and lipase. Biochemistry 1999, 38, 9971-9981. (NSC 87-2113-M005-014 and NSC 88-2113-M005-007), SCI impact factor 3.633, 79/262 (biochemistry & molecular biology), corresponding author.

42.  Gialih Lin,* Chuen-Tzwu Shieh, Yi-Chin Tsai, Ching-Ing Hwang, Chun-Ping Lu, and Gan-Hong Chen. Structure-reactivity probes for active site shapes of cholesterol esterase by carbamate inhibitors. Biochimica et Biophysica Acta, 1999, 1431, 500-511. (NSC 87-2113-M005-014 and NSC 88-2113-M005-007), SCI impact factor 3.311, 93/262 (biochemistry & molecular biology), corresponding author.

43.  林家立, 台北故宮博物院藏三犧尊之研究,中國文物世界, 1999, 172, 60-61. 中文, 通信作者.

44.  Gialih Lin,* Wen-Yuan Lin, and Chuen-Tzwu Shieh. The enhancement of enantioselectivities for lipase-catalyzed reactions by using carbamates. Tetrahedron Letters 1998, 39, 8881-8884. (NSC 87-2113-M005-014), SCI impact factor 2.509, 22/56 (chemistry, organic), corresponding author.

45.  Gialih Lin,* Gan-Hong Chen, and Hong-Chi Ho. Conformationally restricted carbamate inhibitors of horse serum butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters 1998, 8, 2747-2750. (NSC 87-2113-M005-014), SCI impact factor2.538, 11/35 (chemistry, medicinal) or 21/56 (chemistry, organic), corresponding author.

46.  Gialih Lin,* Yi-Chin Tsai, Hsiao-Chien Liu, Wei-Cheng Liao, and Chun-Hui Chang. Enantiomeric inhibitors of cholesterol esterase and acetylcholinesterase. Biochimica et Biophysica Acta, 1998, 1388, 161-174. (NSC 86-2113-M005-014), SCI impact factor 3.311, 93/262 (biochemistry & molecular biology), corresponding author.

47.  Gialih Lin* and Wen-Yuan Lin. Microwave-promoted lipase-catalyzed reactions. Tetrahedron Letters 1998, 39, 4333-4336. (NSC 86-2113-M005-014), SCI impact factor 2.509, 22/56 (chemistry, organic), corresponding author.

48.  Gialih Lin. Enzymed-catalyzed asymmetric reactions. 化學 Chemistry (The Chinese Chemical  Society., Taiwan), 1997, 54, 59-66. (NSC 85-2113-M005-005 and NSC 86-2113-M005-014), 中文, 通信作者.

49.  Gialih Lin, Asymmetric cyclopropanation. 化學Chemistry (The Chinese Chemical Society., Taiwan), 1996, 54, 149-156. (NSC 85-2113-M005-005 and NSC 86-2113-M005-014),中文, 通信作者.

50.  Gialih Lin,* Hsiao-Chien Liu, and Yi-Chin Tsai. Atropisomeric carbamoyl type inhibitors of pancreatic cholesterol esterase. Bioorganic & Medicinal Chemistry Letters, 1996, 6, 43-46. (NSC 85-2113-M005-005 and NSC 86-2113-M005-014), SCI impact factor 2.538, 11/35 (chemistry, medicinal) or 21/56 (chemistry, organic), corresponding author.

51.  Gialih Lin* and Cheng-Yue Lai, Linear free energy relationships of the inhibition of pancreatic cholesterol esterase by 4-nitrophenyl-N-alkylcarbamate, Tetrahedron Letters, 1996, 37, 193-196. (NSC 85-2113-M005-005 and NSC 86-2113-M005-014), SCI impact factor 2.509, 22/56 (chemistry, organic), corresponding author.

52.  Gilih Lin,* Hsiao-Chien Liu, and Sih-Huang Liu. Azeotropic distillation and ultrasound-promoted lipase-catalyzed reactions. Journal Chinese Chemical Society, 1995, 42, 957-961. (NSC 83-0208-M005-006, NSC 84-2118-M005-001, and NSC 85-2113-M005-005), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

53.  Gialih Lin* and Cheng-Yue Lai. Hammett analysis of the inhibition of pancreatic cholesterol esterase by substituted phenyl-N-butylcarbamate. Tetrahedron Letters, 1995, 36, 6117-6120. (NSC 84-2118-M005-001), SCI impact factor 2.509, 22/56 (chemistry, organic), corresponding author.

54.  Gialih Lin* and Hsiao-Chien Liu. Ultrasound-promoted lipase-catalyzed reactions. Tetrahedron Letters, 1995, 36, 6067-6068. (NSC 84-2118-M005-001) SCI impact factor 2.509, 22/56 (chemistry, organic), corresponding author.

55.  Gialih Lin,* Show-Jane Chen, and Hwey-Lin Sun. Multiple enantioselection by an enzyme-catalyzed transacylation. Journal Chinese Chemical Society 1994, 41, 459-465. (NSC 83-0208-M005-006), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

56.  Gialih Lin,* Show-Jane Chen, and Fang-Chen Wu. Conformational analysis of bipheny1-2,2’-diacetate. Journal Chinese Chemical Society 1994, 41, 409-412. (NSC 83-0208-M005-006) SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

57.  Hsiao-Chien Liu, Fang-Chen Wu, Show-Jane Chen, and Gialih Lin.* Synthesis of aryl α,α-difluoroalkyl ketones as potent inhibitors of cholesterol esterase. Journal Chinese Chemical Society, 1994, 41, 103-108. (NSC83-0208-M005-006), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

58.  Fang-Chen Wu and Gialih Lin.* Phospholipase A2-catalyzed hydrolysis of 1,2-dimyristoyl -sn-glycero-3-phosphocholine in organic solvents. Journal Chinese Chemical Society, 1994, 41, 97-102. (NSC83-0208-M005-006), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

59.  Gialih Lin. Status and prospects of enzymes in organic synthesis. 化學 Chemistry (The Chinese Chemical  Societ., Taiwan), 1993, 51, 324-328. (NSC 81-0208-M005-507), 中文, 通信作者.

60.  Shih-Huang Liu, Fang-Chen Wu, Hwey-Lin Sun, and Gialih Lin.* The Phospholipase A2 Catalyzed Acylation of Lysophosphatidylcholine, 化學 Chemistry (The Chinese Chemical  Societ., Taiwan) 1993, 51, 347-356. (NSC 81-0208-M005-507), 中文, 通信作者.

61.  Gialih Lin*, Shih-Huang Liu, Show-Jane Chen, Fang-Chen Wu, and Hwey-Lin Sun. Triple enantioselection by an enzyme-catalyzed transacylation reactions. Tetrahedron Letters 1993, 34, 6057-6058. (NSC 81-0208-M005-507), SCI impact factor 2.509, 22/56 (chemistry, organic), corresponding author.

62.  Gialih Lin*, Shih-Huang Liu, Fang-Chen Wu, and Wei-Jou Jen. Novel acyl donors for enzyme-catalyzed transacylation reactions. Synthetic Communications 1993, 23, 2135-2138. (NSC 81-0208-M005-507), SCI impact factor 1.001, 36/56 (chemistry, organic), corresponding author.

63.  Gialih Lin*, Fang-Chen Wu, and Shih-Huang Liu. Phospholipase A2 catalyses in organic media, Tetrahedron Letters 1993, 34, 1959-1962. (NSC 81-0208-M005-507), SCI impact factor 2.509, 22/56 (chemistry, organic), corresponding author.

64.  Gialih Lin* and Shih-Huang Liu. Lipase-catalyzed transacylation reactions in azeotropic distillations. Organic Preparations and Procedures International 1993, 25, 463-466. (NSC 81-0208-M005-507), SCI impact factor 0.742, 45/56 (chemistry, organic), corresponding author.

65.  Gialih Lin*, Shih-Huang Liu, and Fang-Chen Wu. Synthesis of 1,2-dipalmitoyl-sn-glycero- 3-phospho-1’-myo-inositol and 1,2-dipalmitoyl-sn-glycero-3-phosphorothio-1’-myo-inositol. Journal of the Chinese Chemical Society 1993, 40, 81-86. (NSC 81-0208-M005-507), SCI impact factor 0.577, 88/124 (chemistry, multidisciplinary), corresponding author.

66.  Gialih Lin, C. Frank Bennett, and Ming-Daw Tsai.* Phospholipids chiral at phosphorus.  Stereochemical mechanism of reactions catalyzed by phosphatidylinositide-specific phospholipase C from Bacillus cereus and guninea pig uterus. Biochemistry 1990, 29, 2747-2757. SCI impact factor 3.633, 79/262 (biochemistry & molecular biology), first author.

67.  Gialih Lin and Ming-Daw Tsai.* Phospholipids chiral at phosphorus. 18. Synthesis of thiophosphatidylinositol and stereochemistry of phosphatidylinositide-specific phospholipase C. Journal of the American Chemical Society 1989, 111, 3099-3101. SCI impact factor 7.696, 7/124 (chemistry, multidisciplinary), first author.

68.  Gialih Lin, Joseph Noel, William Loffredo, Henry Z. Sable, and Ming-Daw Tsai.* Use of short-chain cyclopentano phosphatidylcholines to probe the mode of activation of phospholipase A2 from bovine pancreas and bee venom. Journal of Biological Chemistry 1988, 263, 13208-13214. SCI impact factor 5.808, 39/262 (biochemistry & molecular biology), first author.

B. 研討會論文 (Conference Abstracts) (red: international, black: national)

1.      Gialih Lin. Activation mechanisms of lipase and butyrylcholinesterase by carbamates.  42nd EUCHEM Conference on Stereochemistry. 2007, Fürigen-Bürgenstock, Switzerland, April 14-20. 2007.

2.      Yu-Fang Shen, Shyh-Ying Chiou, Gin-Win Lai, Long-Yau Lin, and Gialih Lin. Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro. 2006 Annual Meeting of Chemical Society Taipei, Tamkang University, Taipei, Taiwan, Nov. 24-26, 2006.

3.      Shu-Shien Lin and Gialih Lin. Structure-reactivity Relationships as Probes to Acetylcholinesterase Inhibition Mechanisms by Aryl Carbamates Hammett-Taft Cross-interaction. 2006 Annual Meeting of Chemical Society Taipei, Tamkang University, Taipei, Taiwan, Nov. 24-26, 2006.

4.      Gialih Lin. Probing stereoselective inhibition of the acyl binding site of cholesterol esterase with four diastereomers of 2’-N-alpha-methylbenzylcarbamyl-1,1’-bis-2-naphthol. Poster presentation. 41th EUCHEM Conference on Stereochemistry. 2006, Bürgenstock, Switzerland, April 22-28. 2006.

5.      Gialih Lin. Ortho effects for inhibition mechanisms of butyrylcholinesterase by o-substituted phenyl N-butylcarbamates and comparison with acetylcholinesterase, cholesterol esterase, and lipase. Invited speaker. Oral presentation. 2005年藥物化學研討會, 南投溪頭, Sep. 4-6, 2005.

6.      Gialih Lin. QSAR for conformationally constrained inhibitors of phospholipase A2.  Poster presentation. 2005年藥物化學研討會, 南投溪頭, Sep. 4-6, 2005.

7.      Gialih Lin. QSARs for the steady and pre-steady states of acetylcholinesterase inhibition by aryl carbamates. Poster presentation. 2005年藥物化學研討會, 南投溪頭, Sep. 4-6, 2005.

8.      Gialih Lin. QSARs for triple inhibitions of acetylcholinesterase, butyrylcholinesterase, and Pseudomonas species lipase by biphenyl-4-acyoxylate-4’-N-butylcarbamates. Poster presentation. 2005年藥物化學研討會, 南投溪頭, Sep. 4-6, 2005.

9.      Gialih Lin. A rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by 1,n-alkane-di-N-butylcarbamates. Poster presentation. The 14th European Symposium on Organic Chemistry, Helsinki, Finland, July 4-8, 2005.

10.  林家立, 吳宜桓, 化學戰劑之化學原理:乙醯膽鹼酯酵素抑制反應機理, 陸軍官校八十一週年校慶學術研討會, 化學與國防之關係, 邀請演講, 高雄鳳山, May 27, 2005

11.  林家立, 蔡怡弘, 蔡厚仁, 吳宜桓, 戰爭與和平: 籠狀化合物之超級炸彈與其抑制乙醯膽鹼酯酵素之反應機理, 陸軍官校八十一週年校慶學術研討會, 化學與國防之關係, 壁報論文, 高雄鳳山, May 27, 2005.

12.  Gialih Lin,* Yan-Fu Lin, Mei-Ting Hwang, and Yue-Zen Lin.  Benzene-di-N-octylcarbamates as conformationally constrained phospholipase A2 inhibitors. Poster presentation. International Symposium on Advances in Synthetic, Combinatorial and Medicinal Chemistry (ASCMC), Moscow, Russia, May 5-8, 2004.

13.  Gialih Lin and Chung-Hwey Chan.  Structure-reactivity relationships for the pre-steady-state inhibition of acetylcholinesterase by 4-nitrophenyl-N-substituted carbamates. Poster presentation. 9th European Symposium on Organic Reactivity (ESOR IX), 2003, Oslo, Norway, July 12-17, 2003.

14.  Gialih Lin.  Cross-interaction correlations for the enzyme inhibition by carbamates. Poster presentation. From Solid State to Biophysics. 2002, Dubrovnik, Croatia, June 13-19, 2002.

15.  Gialih Lin.  The opposite stereospecificities for cholesterol esterase and lipase toward enantiomeric substrates and inhibitors. Poster presentation. 36th ESF/EUCHEM Conference on Stereochemistry. 2001, Bürgenstock, Switzerland, April 28-May 4. 2001.

16.  Gialih Lin.  The Hammett-Taft cross-interaction correlations for the inhibition mechanism of cholesterol esterase by substituted phenyl-N-substituted carbamates. Poster presentation. The Sixth International Symbosium for Chinese Organic Chemists. Shanghai, China, July. 28-31, 2000.

17.  Gialih Lin.  The Opposite stereospecificities for cholesterol esterase or lipase toward enantiomeric substrates and inhibitors. Poster presentation. The Eighth International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto, Japan, July. 11-15, 2000.

18.  Gilih Lin. The Opposite stereospecificities for cholesterol esterase or lipase toward enantiomeric substrates and inhibitors. Invited speaker. Enzymatic Synthesis of Biologically Active Compounds. Taipei, Taiwan,, April 25-28, 2000.

19.  Gialih Lin.. Microwave-promoted lipase-catalyzed reactions. Invited speaker. Application of Microwave in Organic Synthesis. Taichung, Taiwan, , April 16, 1999.

20.  Gialih Lin,* Wen-Yuan Lin, and Chuen-Tzwu Shieh.  The enhancement of enantioselectivities for lipase-catalyzed reactions by using carbamates. Invited speaker. 1998 International Symposium on Organic Reactions.  Hsinchu, Taiwan, Nov. 12-15, 1998.

21.  Gialih Lin, Gan-Hong Chen, and Hong-Chi Ho. Conformationally restricted carbamate inhibiors of horse serum butyrylcholinesterase. Poster presentation. 1998 Chinese Chemical Society National Meeting, Chia-I, Taiwan, Nov 29, 1998.

22.  Gialih Lin, Yuh-Cherng Liu, and Wen-Yuan Lin. Microwave-promoted lipase-catalyzed reactions. Poster presentation. 1998 Chinese Chemical Society National Meeting, Chia-I, Taiwan, Nov 29, 1998.

23.  Chun-Hui Chang and Gialih Lin. The mechanistic studies on the inhibitions of acetylcholinesterase and butyrylcholinesterase by 2,2’-biphenyl-2-N-alkylcarbamate-2’-ol and p-nitrophenyl-N-alkylcarbamate. Poster presentation. 1998 Chinese Chemical Society National Meeting, Chia-I, Taiwan, Nov 29, 1998.

24.  Yuh-Cherng Liu and Gialih Lin. The mechanistic studies on the inhibitions of acetylcholinesterase, butyrylcholinesterase, cholesterol esterase, and lipase by 2,2’-biphenyl-2-N-alkylcarbamate-2’-ol and p-nitrophenyl-N-alkylcarbamate. Poster presentation. 1998 Chinese Chemical Society National Meeting, Chia-I, Taiwan, Nov 29, 1998.

25.  Gialih Lin and Cheng-Yue Lai. Linear free energy relationships of the inhibition of pancreatic cholesterol esterase by 4-nitrophenyl-N-alkylcarbamate. Poster presentation. 1995 Chinese Chemical Society National Meeting, Taichung, Taiwan, Nov 24-26, 1995.

26.  Gialih Lin and Hong-Chee Ho. Linear free energy relationships of the inhibition of pancreatic cholesterol esterase by phenyl-N-alkylthioncarbamate. Poster presentation. 1995 Chinese Chemical Society National Meeting, Taichung, Taiwan, Nov 24-26, 1995.

27.  Gialih Lin and Cheng-Yue Lai. Linear free energy relationships of the inhibition of pancreatic cholesterol esterase by substituted phenyl-N-butylcarbamate. Poster presentation. 1995 Chinese Chemical Society National Meeting, Taichung, Taiwan, Nov 24-26, 1995.

28.  Gialih Lin and Ching-Ing Hwang. Linear free energy relationsips of the inhibition of pancreatic cholesterol esterase by glyceryl-1,2,3-tri-N-alkylcarbamate. Poster presentation. 1995 Chinese Chemical Society National Meeting, Taichung, Taiwan, Nov 24-26, 1995.

29.  Gialih Lin Cheng-Yue Lai, and Chuen-Tzwu Shieh. Isoequilibrium and isokinetic temperatures of the inhibition of cholesterol esterase by carbamates. Poster presentation. 1995 Chinese Chemical Society National Meeting, Taichung, Taiwan, Nov 24-26, 1995.

30.  Gialih Lin, Cheng-Yue Lai, and Bing-Hong Kuo. Linear free energy relationships studies on substituted phenyl-N-butylcarbamate. Poster presentation. 1995 Chinese Chemical Society National Meeting, Taichung, Taiwan, Nov 24-26, 1995.

31.  Gialih Lin and Yuh-Yu Lin. The research of inhibition mechanism of acetylcholinesterase. Poster presentation. 1995 Chinese Chemical Society National Meeting, Taichung, Taiwan, Nov 24-26, 1995.

32.  Gialih Lin and Yuh-Yu Lin 1995. The study on the mechanism of antidote of nerve gas in chemical warfare. Invited speaker. The Fourth National Conference on Science and Technology of National Defense, Chung Cheng Institute of Technology, Ta-His, Taw-yuan, Taiwan, Nov. 4, 1995.

33.  Gialin Lin, Hsiao-Chien Liu, Wei-Jou Jen, and Yi-Chin Tsai 1994. The inhibition of cholesterol esterase by carbamates. Poster presentation. 1994 Chinese Chemical Society National Meeting, Hsinchu, Taiwan, Dec 10-12, 1994.

34.  Gialih Lin and Hsiao-Chien Liu 1994. Ultrasound-promoted lipase-catalyzed hydrolysis of rac-1,2,3,4-tetrahydrol-1-naphthylbutyrate. Poster presentation. 1994 Chinese Chemical Society National Meeting, Hsinchu, Taiwan, Nov 25-27, 1994.

35.  Gialih Lin, Shih-Huang Liu, and Show-Jane Chen 1994. Multiple enantioselection by an enzyme-catalyzed transacylation reaction. Oral presentation. The Sixth International Kyoto Conference on New Aspects of Organic Chemistry, Kyoto, Japan, Nov. 7-11, 1994.

36.  Gialih Lin and Fang-Chen Wu. The phospholipase A2 catalyzed in organic solvents. Poster presentation. 1993 Chinese Chemical Society National Meeting, Tainan, Taiwan, Dec 10-12, 1993.

37.  Gialih Lin and Show-Jane Chen. Conformational Analyses of Biphenyl-2,2’-diacetate and Biphenol. Poster presentation.  1993 Chinese Chemical Society National Meeting, Tainan, Taiwan, Dec 10-12, 1993.

38.  Gialih Lin and Hwey-Lin Sun. Enzyme catalyzed transglycosylation in organic solvents. Poster presentation. 1993 Chinese Chemical Society National Meeting, Tainan, Taiwan, Dec 10-12, 1993.

39.  Gialih Lin and Wei-Jou Jen. Resolution of 2-decalols by enzymes. Poster presentation. 1993 Chinese Chemical Society National Meeting, Tainan, Taiwan, Dec 10-12, 1993.

40.  Gialih Lin and Hsiao-Chien Liu. Synthesis of aryl α,α-difluoroalkyl ketones as potent inhibitors of cholesterol esterase. Poster presentation. 1993 Chinese Chemical Society National Meeting, Tainan, Taiwan, Dec 10-12, 1993.

41.  Gialih Lin. The development of a novel pharmaceutical in the treatment of arteriosclerosis. Invited speaker. The 8th Symposium on Natural Products. Kaohsiung, Taiwan, Aug 13-14, 1993.

42.  Shih-Huang Liu, and Gialih Lin. The enzyme catalyzed acylation of lysophosphatidylcholine. Poster presentation. The 8th Symposium on Natural Products, Kaohsiung, Taiwan, Aug 13-14, 1993.

43.  Gialih Lin, Shih-Huang Liu, Show-Jane Chen, and Hwey-Lin Sun. Triple enantioselection by an enzyme-catalyzed transacylation reaction. Poster presentation. The 11th R.O.C. Symposium on Catalysis and Reaction Engineering, Taipei, Taiwan, June 25-26, 1993.

44.  Gialih Lin, Fang-Chen Wu, Shih-Huang Liu, and Hwey-Lin Sun. Phospholipase A2 catalyses in organic solvents. Poster presentation. The 11th R.O.C. Symposium on Catalysis and Reaction Engineering, Taipei, Taiwan, June 25-26, 1993.

45.  Gialih Lin, Shih-Huang Liu, Fang-Chen Wu, and Hwey-Lin Sun. Triple enantioselection by an enzyme-catalyzed transacylation reaction. Poster presentation. The 33rd National Organic Symposium, Bozeman, MT, USA, June 13-17, 1993.

46.  Gialin Lin and Shih-Huang Liu. Lipase-catalyzed transacylation reactions in azeotropic distillations. Poster presentation. The 33rd National Organic Symposium, Bozeman, MT, USA, June 13-17, 1993.

47.  Gialih Lin and Shih-Huang Liu. Novel acyl donors for enzyme-catalyzed transacylation reactions. Poster presentation. The 33rd National Organic Symposium, Bozeman, MT, USA, June 13-17, 1993.

48.  Gialih Lin, Fang-Chen Wu, and Shih-Huang Liu. Phospholipase A2 catalyses in organic media. Poster presentation. The 33rd National Organic Symposium, Bozeman, MT, USA, June 13-17, 1993.

49.  Gialih Lin, Shih-Huang Liu, and Fang-Chen Wu. Synthese of 1,2-dipalmitoyl-sn-glycero-3-phospho-1’-myo-inositol and 1,2-dipalmitoyl-sn-glycero-3- phosphorothio-1’-myo-inositol. Poster presentation. The 33rd National Organic Symposium, Bozeman, MT, USA, June 13-17, 1993.

C. 專書及專書論文 (Books) (black: in Chinese, blue: in English)

1.      林家立，實用生活化學，2002，滄海書局出版。

2.      林家立，不對稱環丙烷化反應，pp89-102，書名:不對稱合成與催化，1998，中興大學文教基金會出版。

3.      林家立，酵素催化不對稱反應，pp211-223，書名:不對稱合成與催化，1998，中興大學文教基金會出版。

4.      Karol S. Bruzik, Gialih Lin, and Ming-Daw Tsai, Phosphorothioate Analogues of Phosphatidylinositol and Inositol 1,2-Cyclic Phosphate: Application to Mechanism of Phospholipase C, pp 172-185, Inositol Phosphates and Derivatives. Allen B. Reitz, Editor.  ACS Symposium Series 1991, 463, 172-185.

5.      Gialih Lin, Stereochemistry and Mechanism of Phospholipase A2 and Phosphatidylinositide- Specific Phospholipase C, Ph. D. Dissertation, Advisor: Ming-Daw Tsai, Department of Chemistry, The Ohio State University, USA, 1989, 195 pages.

國立中興大學化學系National Chung Hsing University Department of Chemistry

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