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分子細胞生物學/生物化學 Molecular/Cellular Biology / |
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1.
B. S., National Chung Hsing University (1990-1994) 2.
Research Student, Tohoku University (Japan) (1994-1995) 3.
M. S., Tohoku University (Japan) (1995-1997) 4.
Ph. D., Tohoku University (Japan) (1997-2000) 5.
Postdoctoral Fellow, The University of Tokyo (Japan) (2000-2002) 6.
Research Fellow, Japan Health Science Foundation (2001-2002) 7.
Assistant Professor, National Chung-Hsing University (2002~2010) 8.
Associate Professor, National Chung Hsing University (2010-) |
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細胞分化機構與訊息傳遞,基因選殖與表現,基因轉錄調控機構解析,本研究室可分成三大方向: 1. 細菌素機能與調控機構解析 2.
細菌素胞外分泌機制解析 3.
人類細胞激素多型性表現與臨床疾病關係解析 |
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(A)
期刊論文 1.
Y.-C. Chan, H.–P.
Wu, and D.-Y. Chuang . 2009.
Extrecellular secretion of Carocin S1 in Pectobacterium carotovorum subsp. carotovorum occurs via the
type III secretion system integral to the bacterial flagellum. BMC
Microbiology (revised, 通訊作者) 2.
H.-P. Wu, C.-K. Chen, K. Chung, J.-C.
Tseng, C.-C. Hua, Y.-C. Liu, D.-Y. Chuang, C.-H. Yang. 2009. Serial Cytokine Levels in Patients
with Severe Sepsis. Inflamm.
Research 23:519-524 (in press, SCI= 1.602、合作論文) 3.
H.-P. Wu, C.-K.
Chen, K. Chung, B.-Y. Jiang, T.-J. Yu, D.-Y. Chuang. 2009. Plasma Transforming Growth Factor-β1 Level in Patients with Severe Community-acquired Pneumonia and
Association with Disease Severity. J Formos Med Assoc 108:20-27 (SCI=0.5, 合作論文) 4.
H.-P. Wu; C.-L. Wu; C.-K. Chen; K. Chung;
J.-C. Tseng; Y.-C. Liu, and D.-Y. Chuang. 2008. The Interleukin-4 Expression in Patients with Severe
Sepsis. J. Critical Care 23:519-524 (SCI=2.048, 通訊作者) 5.
C-Y. 6.
D.-Y Chuang, Y.-C Chien, and H.P. Wu. 2007.
Cloning and Expression of the Erwinia carotovora subsp. carotovora Gene
Encoding the Low-Molecular-Weight Bacteriocin, Carocin S1, J. Bacteriol. 189:
620-629 (SCI=4.167, 第一作者、通訊作者 ) 7.
H.-P. Wu, C.-C. Hua, Y.-C. Liu, D.-Y. Chuang. 2007. Comparison of interferon-g
response between tuberculosisand non-tubercular Pneumonia. Inflamm. Research
56: 11-16 (SCI= 1.602、合作論文 ) 8.
H.-P. Wu , C.-C. Hua, D.-Y. Chuang. 2007. Decreased in vitro interferon-γproduction in patients with
cavitary tuberculosis on chest radiography. Respiratory Medicine 101: 48-52
(SCI=1.663、合作論文 ) 9.
H.-P. Wu, C.-L. Wu, C.-C. Yu, Y.-C. Liu, D.-Y. Chuang. 2007. Efficiency of interleukin-4
expression in patients with tuberculosis and nontubercular pneumonia. Human
Immunology 68: 832-838(SCI=2.664, 通訊作者 ) 10.
Kyeremeh, A.G., Kikumoto, T., Chuang, D.Y., Gunji, Y.,
Takahara, Y. and Ehara, Y. 2000. Biological
Control of Soft Rot of Chinese Cabbage Using Single and Mixed Treatments of
Bacteriocinproducing Avirulence Mutants of Erwinia carotovora subsp.
Carotovora J. Gen. Plantpathol. 66:264-270. 11.
Kyeremeh, A.G., Kikumoto, T., Chuang, D.Y., Takahara,
Y. and Ehara, Y. 1999. Studies on
integration of bactericide-resistant biocontrol agents into conventional
copper-bactericide sprays. Ann. Phytopathol. Soc. Jpn. 65: 571-575. 12.
Kyeremeh, A.G., Kikumoto, T., Chuang, D.Y., Gunji, Y.
and Takahara, Y. 1999. Isolation
and evaluation of copper- and bactericide-resistant mutants of putative
biocontrol agents of soft rot of Chinese cabbage. Ann. Phytopathol. Soc. Jpn.
65: 171-176. 13.
Chuang, D.Y., Kyeremeh, A. G., Gunji, Y., Takahara, Y.,
Ehara, Y., and T. Kikumoto. 1999.
Identification and Cloning of an Erwinia carotovora subsp. carotovora
bacteriocin regulator gene by insertional mutagenesis. J. Bacteriol.
181:1953-1957. 14.
Kyeremeh, A.G., Kikumoto, T., Chuang, D.Y., Gunji, Y.
and Ehara, Y. 1998. Evaluation of
copper- and bactericide- resistance among strains of Erwinia carotovora
subsp. carotovora. Ann. Phytopathol. Soc. Jpn. 64: 198-201. (B)
研討會論文 1.
Wu, C.
K., and Chuang, D. Y. 2004. Studies of Bacteriocin Genes
and Structure of Erwinia carotovora subsp. Carotovora. 93 年中國化學學會年會 2.
莊敦堯, 邱富斌. 2004.
Oncostatin M 在非肝細胞中誘導tyrosine amino transferase 基因中 intron A 區域的組織特異性抑制子活性. 93 年中國化學學會年會 3.
Chan, Y.
C.; Chuang, D. Y. 2005.
Erwinia carotovora Low-Molecular-Weight Bacteriocin Protein Export Utilizes a
Type Ⅲ-like Secretion System. Ann. Mol. Biol. 2005. 4.
Wu, H.
P., Hua, C. C., and Chuang, D. Y. 2005. Chest
Radiography Patterns with IFN-Gamma and IL-4 Production in Pulmonary
Tuberculosis Ann. Mol. Biol. 2005. 5.
Wu, H.
P., Hua, C. C., and Chuang, D. Y. 2006.
Interleukin-4 Expression in Patients with Severe Sepsis Type of Presentation.
20th IUBMB International Congress of Biochemistry and Molecular Biology and
11th FAOBMB Congress, 2006, Kyoto, Japan. 6.
詹永傑、莊敦堯. 2006. Erwinia carotovora subsp. carotovora低分子量細菌素選殖與表現 95年中國化學學會年會、台北 7.
Chan, Y.
C., Wu, C. L., and Chuang, D.
Y.
Gene Cloning and Identification of Low-Molecular-Weight Bacteriocin, carocin
S2, from Erwinia carotovora subsp. carotovora. American Society for
Microbiology General 107th Meeting 2007, Toronto, Canada 8.
Wu, H.
P., Hua, C. C., and Chuang, D. Y. 2006. Interleukin-4
Expression in Patients with Severe Sepsis Type of Presentation. American
Society for Microbiology General 107th Meeting 2007, Toronto, Canada 9.
Chuang, D. Y., Chan, Y. C., and Wu, C. L. Gene Cloning and
Identification of Low-Molecular-Weight Bacteriocin, carocin S2, from Erwinia
carotovora subsp. carotovora. 2007 Annual
Meeting of the Molecular Biology Society of Japan & the Japanese
Biochemical Society, Yokohama, Japan 10.
Wu, H. P., Hua, C. C., Yu, C. C., Chu, C. M., Chuang, D. Y. Low
Interleukin-12 Response Decrease Interferon-gamma Response in Tuberculosis
Patients. 2008 Annual Meeting of the Molecular Biology Society of Japan &
the Japanese Biochemical Society, Kobe, Japan 11.
黃玉珊、吳黃平、莊敦堯. 2008. The Expression of INF-γ
Gene in Patients with Tuberculosis and Spesis. 97年生物醫學聯合學術年會、台北 12.
吳建利、莊敦堯. 2008. Cloning, Expression, and
Purification of the CaroS2, the Immunity Protein of Carocin S2, from Erwinia
carotovora. 97年生物醫學聯合學術年會、台北 13.
Chan, Y-c., and Chuang, D. Y. Cloning and
Expression of the Erwinia carotoovra Gene Encoding the
Low-Molecular-Weight Bacteriocin Carocin S2. American Society for
Microbiology General 109th Meeting 2009, Philadelphia, USA (C) Abstracts: 1.
Chuang, D. Y., Matsui, T., and Miyajima, A., 2001. Regulation of Tyrosine Amino
Transferase Expression through STAT3 and C/EBPα in Fetal Liver. Workshop of
Hepatocytes, 2002. 2.
Chuang, D. Y., Matsui, T., Kinoshita, T., and Miyajima,
A. 2001.Oncostatin M regulates
expression of tyrosine amino transferase gene through STAT3 and C/EBPα. Ann. Mol. Biol.
2001. 3.
Chuang, D. Y., Matsui, T., Kinoshita, T., and Miyajima,
A. 2001. Regulation of Tyrosine
Amino Transferase Expression by Oncostatin M in Fetal Liver. 4th IMCBNS,
Taipei, Taiwan. 4.
Chuang, D. Y., Matsui, T., Kinoshita, T., and Miyajima,
A., 2001. Regulation of Tyrosine Amino Transferase Expression by Oncostatin M
in Fetal Liver. Workshop of Hepatocytes, 2001. 5.
Chuang, D.Y., Kyeremeh, A. G., and T. Kikumoto. 2000. Cloning and Expression of the
Erwinia carotovora subsp. Carotovora Gene Encoding the Low-Molecular-Weight
Bacteriocin, H1. Ann. Phytopathol. Soc. Jpn. 66: 138. 6.
Chuang, D.Y., Kyeremeh, A. G., and T. Kikumoto. 1998. Diverse Bacteriocins Produced
by Erwinia carotovora subsp. Carotovora Ann. Phytopathol. Soc. Jpn. 64:
608-609. 7.
Chuang, D.Y., Kyeremeh, A. G., Gunji, Y., Takahara, Y.,
and T. Kikumoto. 1998. Cloning of
Bacteriocin Regulator gene (brg) from Erwinia carotovora subsp. Carotovora.
Ann. Phytopathol. Soc. Jpn. 64:389-390. 8.
Kyeremeh, A.G., Chuang, D.Y., Gunji, Y., Takahara, Y.,
and Kikumoto, T. 1998. Isolation
and Evaluation of Copper- and Bacteriocide- resistant Mutants of Putative
Biocontrol Agents of the Soft-rot Disease of Chinese Cabbage. Ann. Phytopathol.
Soc. Jpn. 64: 385. 9.
Kikumoto, T., Kyeremeh, A. G., Chuang, D. Y., and
Gunji, Y. 1997. Biological control
of the soft rot disease of Chinese cabbage with avirulent mutant strains of
Erwinia carotovora subsp. Carotovora. Proc. 4th Intl. Workshop on PGPR,
Japan-OECD Joint Workshop, Sapporo, pp. 118-119. 10.
Kyeremeh, A.G., Chuang, D.Y., Gunji, Y., and Kikumoto,
T. 1996. Copper-resistance in
Erwinia carotovora subsp. Carotovora. Ann. Phytopathol. Soc. Jpn. 62: 605. (D) Preparation
Articles: 1.
Chuang, D. Y., Kyeremeh, A. G., and Kikumoto, T.
Induction of Bacteriocin Synthesis in Erwinia carotovora subsp. Carotovora is
controlled by the expression of flhDC. (Preparation) 2.
Chuang, D. Y., Kyeremeh, A. G., and Kikumoto, T.
Cloning and Expression of Erwinia carotovora subsp. carotovora Gene Encoding
the Low-Molecular-Weight Bacteriocin, Carocin H1. (Preparation) 3.
Chuang, D. Y., and Kikumoto, T. New Induction and
Regulatory Mechanism of the Low-Molecular-Weight Bacteriocin Expression in
Erwinia carotovora subsp. carotovora. (Preparation) 4.
Chuang, D. Y., Matsui, T., and Miyajima, A. Cooperation
of STAT3 and C/EBPα for expression of the tyrosine amino transferase gene in mouse
fetal hepatocytes: identification of an Oncostatin M responsive element.
(Preparation) |
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國立中興大學化學系National
Chung Hsing University Department of Chemistry 地址:台中市國光路250號 化學館 電話:04-22840411 傳真:04-22862547 |
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