韓政良
Jeng-Liang Han

有機化學

Organic Chemistry

https://image.jimcdn.com/app/cms/image/transf/dimension=142x1024:format=jpg/path/s55964b120adeb6c5/image/ibbf1dddf98068dd1/version/1505532930/image.jpg

E-mail : jlhan@nchu.edu.tw

Tel : (04)-22840411-ext 306

學經歷

l  Associate Professor, Department of Chemistry, National Chung Hsing University (2019-)

l  Associate Professor, Department of Chemistry, Chung Yuan Christian University (2017-2019)

l  Assistant Professor, Department of Chemistry, Chung Yuan Christian University (2013-2017)

l  Postdoctoral Fellow, Genomics Research Center, Academia Sinica (2012-2013)

l  Research Associate, The Scripps Research Institute, Scripps Florida (2010-2012)

l  Postdoctoral Fellow, Genomics Research Center, Academia Sinica (2007-2010)

l  Ph. D. National Sun Yat-sen University (2000-2005)

l  B. S. National Sun Yat-sen University (1996-2000)

Research Interests:

We are interested in exploring the field of organocatalysis focusing on the development of novel (asymmetric) processes using organocatalytic methods, while advancing a mechanistic understanding of these transformations.

 

Selected Publications:

1.*Han, J.-L.; Chang, C.–H. “Asymmetric assembly of spirooxindole dihydropyranones through direct enantioselective organocatalytic vinylogous aldol/cyclization cascade reaction of 3-alkylidene oxindoles with isatinsChem. Communs 2016, 52, 2322-2325. 

2. Guo, Y.-L.; Li, Y.-H.; Chang, H.-H.; Kuo, T.-S.; *Han, J.-L. “Molecular sieve mediated sequential Knoevenagel condensation/decarboxylative Michael addition reaction: efficient and mild conditions for the synthesis of 3,3-disubstituted oxindoles with an all carbon quaternary center” RSC Advances 2016, 6, 74683-74690.

3. Chang, C.-H.; *Han, J.-L. Organocatalytic Enantioselective Friedel-Crafts Reaction of Sesamol and Electron–rich Phenols with Alkylideneindolenine Intermediates Generated from Arylsulfonyl Indoles” ChemistrySelect, 2016, 1, 5628-5632.

4. Chang, H.-H.; Chu, K.-D.; Chiang, M.-H.; *Han, J.-L. Organocatalytic Enantioselective Michael Reaction of 1,3-Dicarbonyls with α-Substituted β-NitroacrylatesTetrahedron, 2017, 73, 727-734.

5.*Han, J.-L.; Tsai, Y.-D.; Chang, C.-H. “Asymmetric Synthesis of Spirooxindole δ-Lactones with Vicinal Tertiary and Quaternary Stereocenters via Regio-, Diastereo-, and Enantioselective Organocatalytic Vinylogous Aldol−cyclization Cascade Reaction” Adv. Synth. Catal. 2017, 359, 4043-4049.

6.*Han, J.-L.; Liao, Y.-T.; Chang, C.-H. “Asymmetric Organocatalytic Conjugate Addition of Electron-Rich Phenols and 1,3-Dicarbonyls to Arylsulfonyl Indoles in an Oil-Water Biphasic System” Eur. J. Org. Chem. 2019, 5815-5823.

7. Chang, C.-H.; Sathishkumar, N.; Liao, Y.-T.; *Chen, H.-T.; *Han, J.-L. “Solvent-Dependent Enantiodivergent Friedel-Crafts Reaction of Arylsulfonyl Indoles with 1-Naphthols” Adv. Synth. Catal. 2020, 362, 903-912.

8. Guan, R.-Y.; Hsu, C.-W.; *Han, J.-LTrifluoroethanol-mediated Decarboxylative Addition Reactions of β-Ketoacids with Diverse Electrophiles” Asian. J. Org. Chem. 2021, 10, 273-284.

9. Xu, J.-X.; Chu, K.-D.; Chiang, M.-H.; *Han, J.-L. Organocatalytic asymmetric allylic alkylation of 2-methyl-3-nitroindoles: a route to direct enantioselective functionalization of indole C(sp3)-H bonds” Org. Biomol. Chem. 2021, 19, 1503-1507.