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Tel: +886-4-22840411 ext 813 0919-846716
1. 不對稱合成 2. 天然物全合成 3. 開發具生物活性分子的合成方法 4. 潛在抑製劑/抗生素的合成 5. 了解小分子與生物系統的作用關係 |
林正坤 |
有機化學 Organic Chemistry |
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1. B. S., Department of Chemistry, National Chung-Hsing University (1999-2003) 2. M. S., Department of Chemistry, National Chung-Hsing University (2003-2006) 3. Ph. D., Department of Chemistry, National Chung-Hsing University (2006-2011) 4. Postdoctoral Fellow, Genomics Research Center, Academia Sinica (2012–2018) 5.
Assistant Professor, Department of Chemistry,
National Chung-Hsing University (2018-) Award : 2016 GRC outstanding performance award
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1. Asymmetric synthesis 2. Total synthesis of
natural products 3. Development of
efficient synthetic methods for biologically interesting molecules 4. Synthesis of potential
inhibitors/antibiotics inspired from natural sources 5. Understand the
relationships between small molecules and biological systems |
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1. Wei-Chieh Cheng, Cheng-Kun Lin, Huang-Yi Li, Yu-Chien Chang, Sheng-Jhih Lu,
Yu-Shin Chen, Shih-Ying Chang, “A combinatorial
approach towards the synthesis of non-hydrolysable triazole-iduronic
acid-hybrid inhibitors of human α-L-iduronidase: Discovery of enzyme
stabilizers for the potential treatment of MPSI”, Chem. Commun. 2018, accepted. 2. Kuo-Ting Chen, Cheng-Kun
Lin, Chih-Wei Guo, Yi-Fan Chang, Chia-Ming Hu, Hsiao-Han Lin, Yuting
Lai, Ting-Jen R. Cheng, Wei-Chieh Cheng, “Effect
of the Lipid II Sugar Moiety on Bacterial Transglycosylase: the 4-Hydroxy
Epimer of Lipid II is a TGase Inhibitor”, Chem. Commun. 2017,
53, 771−774.. 3. Cheng-Kun Lin,
Chung-Chien Hou, Yi-Yong Guo, Wei-Chieh Cheng, “Design and Synthesis of Orthogonally Protected D- and
L-β-Hydroxyenduracididines from D-lyxono-1,4-Lactone”, Org. Lett. 2016, 18, 5216−5219. 4. Kuo-Ting Chen, Po-Ting Chen, Cheng-Kun
Lin, Lin-Ya Huang, Chia-Ming Hu, Yi-Fan Chang, Hua-Ting Hsu, Ting-Jen
R. Cheng, Ying-Ta Wu, Wei-Chieh Cheng, “Structural
Investigation of Park’s Nucleotide on Bacterial Translocase MraY: Discovery
of Unexpected MraY Inhibitors”, Sci.
Rep. 2016, 6, 31579. 5. Cheng-Kun Lin,
Wen-Yi Yun, Lin-Ting Lin, Wei-Chieh Cheng, “A concise approach to the synthesis of the unique N-mannosyl
D-β-hydroxyenduracididine moiety in the mannopeptimycin series of natural
products”, Org. Biomol. Chem. 2016, 14, 4054–4060. 6. Cheng-Kun Lin,
Kuo-Ting Chen, Chia-Ming Hu, Wen-Yi Yun, Wei-Chieh Cheng, “Synthesis of 1-C-glycoside Linked Lipid
II Analogues toward Bacterial Transglycosylase Inhibition Study”, Chem. Eur. J. 2015, 21, 7511–7519. 7. Wei-Chieh Cheng, Chih-Wei Guo, Cheng-Kun Lin, Yu-Ruei Jiang, “Synthesis and Inhibition Study of Bicyclic Iminosugar-Based
Alkaloids, Scaffolds, and Libraries towards Glucosidase”, Isr. J. Chem. 2015, 55, 403–411. 8. Po-Ting Chen, Cheng-Kun
Lin, Chih-Ju Tsai, Duen-Yi Huang, Fu-Yao Nien, Wan-Wan Lin, Wei-Chieh
Cheng, “Expeditious Synthesis of
Enantiopure, Orthogonally Protected Bis α-Amino Acids (OPBAAs) and their Use
in a Study of Nod1 Stimulation”, Chem.
Asian J. 2015, 10, 474–482. 9. Cheng-Kun Lin,
Li-Wei Cheng, Huang-Yi Li, Wen-Yi Yun, Wei-Chieh Cheng, “Synthesis of Novel Polyhydroxylated Pyrrolidine–triazole/-isoxazole
Hybrid Molecules”, Org. Biomol.
Chem. 2015, 13, 2100–2107. 10.Ta-Jung Lu, Cheng-Kun Lin, “Asymmetric Synthesis of α-Methyl-α-Amino Acids via
Diastereoselective Alkylation of (1S)-(+)-3-Carene-derived Tricyclic
Iminolactone”, J. Org. Chem.
2011, 76, 1621–1633. 11.Cheng-Kun Lin, Ta-Jung Lu, “A Simple Method for the Oxidation of Primary Alcohols with
o-Iodoxybenzoic Acid (IBX) in the Presence of Acetic Acid”, Tetrahedron, 2010, 66, 9688–9693. 12.Ta-Jung Lu, Cheng-Kun Lin, “Asymmetric Synthesis of α-Amino Acids — Preparation and Alkylation of Monocyclic Iminolactones Derived From
α-Methyl-trans-Cinnamaldehyde”, J. Org. Chem. 2008, 73, 9527–9534. |
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