E-mail : lcf0201@dragon.nchu.edu.tw

Tel : (04)-22840411-ext 701

梁健夫
Chien-Fu Liang

有機化學暨生物有機

(Organic & Bioorganic Lab)

l Associate Professor, National Chung Hsing University (2019-)

l Assistant Professor, National Chung Hsing University (2015-2019)

l Postdoctoral research fellow: National Sun Yat-sen University, (2014.11~2015.7)

l Postdoctoral research fellow: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. (2012.11~2014.10)

l Postdoctoral research fellow: National Tsing Hua University (2010.10~2012.9)

l PhD National Tsing Hua University (2005.9-2009.7)

l M.S. National Tsing Hua University (2003.9-2005.7)

l B.S. National Chung Hsing University (2000.9 – 2003.6)

1. 利用金屬催化來合成重要及有趣的有機化合物。

2. 開發新穎有機反應並著重於水相化學鍵結方法，進而應用於生物分子之修飾。

3. 化學生物學:利用有機合成的觀念來設計功能化分子以及複雜寡醣抗原，進而研究重要的生物作用。

1. Using metal catalysts to synthesize important and interesting organic molecules.

2. Development of organic methodology: With particular interest in aqueous reaction systems for application in site-selective chemical modification of biomolecules

3. Chemical Biology: Use the concept of organic chemistry to design the functional probes and the synthesis of complex carbohydrate antigens, to study the biomolecular interaction.

1. Yu-Chen Chou,^‡ Wei-Han Lin,^‡ Xiu-Yi Lin,^‡ Chin-Ling Kuo, Wan-Qin Zeng, I-Chung Lu, and Chien-Fu Liang* “Hexamethyldisilazane-Mediated Amidination of Sulfonamides and Amines with Formamides” J. Org. Chem. 2022. ASAP. (https://doi.org/10.1021/acs.joc.2c01902)

2. Wei-Jr Liao, Sih-Yu Lin, Yu-Shan Kuo, and Chien-Fu Liang* “Site-Selective Acylation of Phenols Mediated by a Thioacid Surrogate through Sodium Thiosulfate Catalysis” Org. Lett. 2022, 24, 4207-4211.

3. Ya-Syuan Li, Chien-Fu Liang* “ Cerium(III) triflate-catalyzed cycloaddition reaction in aqueous conditions to substituted naphthotriazolediones” J. Chin. Chem. Soc. 2022, 69, 849-855.

4. Jia-Yu Wu, Wei-Jr Liao, Xiu-Yi Lin and Chien-Fu Liang* “A facile access to N-sulfonylthioimidates and their use for the transformation to 3,4- dihydroquinazolines” Org. Biomol. Chem. 2020, 18, 8881-8885.

5. Hsin-Yi Huang,^‡ Xiu-Yi Lin,^‡ Shih-Yao Yen and Chien-Fu Liang* “Facile access to N-formyl imide as an N-formylating agent for the direct synthesis of N-formamides, benzimidazoles and quinazolinones” Org. Biomol. Chem. 2020, 18, 5726-5733.

6. Hsin-Yi, Huang, Chien-Fu Liang* “ Sequential Ytterbium(III) Triflate Catalyzed One-Pot Three-Component Thia-Michael Addition” Asian J. Org. Chem. 2018, 7, 955-963.

7. Yen-Sen, Liao, Chien-Fu Liang* “One-Pot Synthesis of Thioester with Sodium Thiosulfate as a Sulfur Surrogate under Transition Metal-Free Conditions” Org. Biomol. Chem. 2018, 16, 1871-1881.

8. Jiun-Rung Guo, Hsin-Yi Huang, Yi-Ling Yan, Chien-Fu Liang* “Selective S-Deacetylation of Functionalized Thioacetates Catalyzed by Dy(OTf)₃” Asian J. Org. Chem. 2018, 7, 179-188.

9. Yi-Ling Yan, Jiun-Rung Guo, Chien-Fu Liang* “Sequential Dy(OTf)₃-Catalyzed Solvent-Free Per-O-Acetylation and Regioselective Anomeric De-O-Acetylation of Carbohydrates“ Chem. Asian J. 2017, 12, 2471-2479.

Cooperation:

1. Ting-Chun Kuan, Hsin-Ru Wu, Avijit K. Adak, Ben-Yuan Li, Chien-Fu Liang, Jung-Tung Hung, Shih-Pin Chiou, Alice L. Yu, Jih Ru Hwu, Chun-Cheng Lin* “Synthesis of an S-Linked α(2→8) GD3 Antigen and Evaluation of the Immunogenicity of Its Glycoconjugate” Chem. Eur. J. 2017, 23, 6876-6887.

2. Heung-Sik Hahm, Chien-Fu Liang, Chian-Hui Lai, Richard J. Fair, Peter H. Seeberger^* “Automated Glycan Assembly of Complex Oligosaccharide Related to Blood Group Determinants” J. Org. Chem. 2016, 81, 5866-5877.

3. Wei-Ting Chien, Chien-Fu Liang, Ching-Ching Yu, Chien-Hung Lin, Si-Peng Li, Kuo-Chu Hwang, Indah Primadona, Yu-Ju Chen, Chun-Cheng Lin^* “Sequential one-pot enzymatic synthesis of oligo-N-acetyllactosamine and its multi-sialylated extensions” Chem. Commun. 2014, 50, 5786-5789.

4. Shiao-Chan Wang, Ching-Ching Yu, Chien-Fu Liang, Li-De Huang, Jih-Ru Hwu, Chun-Cheng Lin^* “Site-selective protein immobilization via 2-cyanobenzothiazole cysteine condensation” ChemBioChem, 2014, 15, 829-835.

5. Wei-Ting Chien, Chien-Fu Liang, Ching-Ching Yu, Jian- Hong Lin, Haung-Ting Wu, Chun-Cheng Lin* “Glucose-1-phosphate Thymidylyltransferasein the Synthesis of Uridine 5'-DiphosphateGalactose and its Application on Synthesis of N-Acetyllactosamine ”Adv. Synth. Catal. 2012, 354, 123-132.

Book Chapter:

1. Chien-Fu Liang, Heung Sik Hahm, and Peter H. Seeberger*; ‘’ Automated Synthesis of Chondroitin Sulfate Oligosaccharides ’’ Methods in Molecular Biology (Clifton, N.J.), 2015, Volume 1229, Chapter 1, 3-10.

2. Wei-Ting Chien, Ching-Ching Yu, Chien-Fu Liang, Chian-Hui, Lai, Po-Chiao Lin, and Chun-Cheng Lin^*; Functional Glyconanoparticles for the Study of Glycobiology Petite and Sweet: Glyco-Nanotechnology as a Bridge to New Medicine, ACS Symposium Series, 2011, Volume 1091, Chapter 2, 15-36.

Awards/Honors/Fellowships:

1. 109學年度中興大學教學特優II

2. 111學年度中興大學優聘教師III

3. Max Planck research fellowship, Max Planck Institute, Berlin, Germany, 2012-2014.

4. Academic published award of postdoctoral researchers, National Science Council, Taiwan, 2013 (國科會博士後研究人員學術著作獎).

5. The Outstanding PhD Thesis Award of Chinese Chemistry Society, 2009 (中國化學學會博士論文傑出獎-有機化學組).

國立中興大學化學系National Chung Hsing University Department of Chemistry

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