E-mail : lcf0201@dragon.nchu.edu.tw

Tel : (04)-22840411-ext 701

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Chien-Fu Liang

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(Organic & Bioorganic Lab)

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l   Associate Professor, National Chung Hsing University (2019-)

l   Assistant Professor, National Chung Hsing University (2015-2019)

l   Postdoctoral research fellow: National Sun Yat-sen University, (2014.11~2015.7)

l   Postdoctoral research fellow: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. (2012.11~2014.10)

l   Postdoctoral research fellow: National Tsing Hua University (2010.10~2012.9)

l   PhD National Tsing Hua University (2005.9-2009.7)

l   M.S. National Tsing Hua University (2003.9-2005.7)

l   B.S. National Chung Hsing University (2000.9 ¡V 2003.6)

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1.   Using metal catalysts to synthesize important and interesting organic molecules.

2.   Development of organic methodology: With particular interest in aqueous reaction systems for application in site-selective chemical modification of biomolecules

3.   Chemical Biology: Use the concept of organic chemistry to design the functional probes and the synthesis of complex carbohydrate antigens, to study the biomolecular interaction.

 

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1. Yu-Chen Chou, Wei-Han Lin, Xiu-Yi Lin, Chin-Ling Kuo, Wan-Qin Zeng, I-Chung Lu, and Chien-Fu Liang* ¡§Hexamethyldisilazane-Mediated Amidination of Sulfonamides and Amines with Formamides¡¨ J. Org. Chem. 2022. ASAP. (https://doi.org/10.1021/acs.joc.2c01902)

2. Wei-Jr Liao, Sih-Yu Lin, Yu-Shan Kuo, and Chien-Fu Liang* ¡§Site-Selective Acylation of Phenols Mediated by a Thioacid Surrogate through Sodium Thiosulfate Catalysis¡¨ Org. Lett. 2022, 24, 4207-4211.

3. Ya-Syuan Li, Chien-Fu Liang* ¡§ Cerium(III) triflate-catalyzed cycloaddition reaction in aqueous conditions to substituted naphthotriazolediones¡¨ J. Chin. Chem. Soc. 2022, 69, 849-855.

4. Jia-Yu Wu, Wei-Jr Liao, Xiu-Yi Lin and Chien-Fu Liang* ¡§A facile access to N-sulfonylthioimidates and their use for the transformation to 3,4- dihydroquinazolines¡¨ Org. Biomol. Chem. 2020, 18, 8881-8885.

5. Hsin-Yi Huang, Xiu-Yi Lin, Shih-Yao Yen and Chien-Fu Liang* ¡§Facile access to N-formyl imide as an N-formylating agent for the direct synthesis of N-formamides, benzimidazoles and quinazolinones¡¨ Org. Biomol. Chem. 2020, 18, 5726-5733.

6. Hsin-Yi, Huang, Chien-Fu Liang* ¡§ Sequential Ytterbium(III) Triflate Catalyzed One-Pot Three-Component Thia-Michael Addition¡¨ Asian J. Org. Chem. 2018, 7, 955-963.

7. Yen-Sen, Liao, Chien-Fu Liang* ¡§One-Pot Synthesis of Thioester with Sodium Thiosulfate as a Sulfur Surrogate under Transition Metal-Free Conditions¡¨ Org. Biomol. Chem. 2018, 16, 1871-1881.

8. Jiun-Rung Guo, Hsin-Yi Huang, Yi-Ling Yan, Chien-Fu Liang* ¡§Selective S-Deacetylation of Functionalized Thioacetates Catalyzed by Dy(OTf)3¡¨ Asian J. Org. Chem. 2018, 7, 179-188.

9. Yi-Ling Yan, Jiun-Rung Guo, Chien-Fu Liang* ¡§Sequential Dy(OTf)3-Catalyzed Solvent-Free Per-O-Acetylation and Regioselective Anomeric De-O-Acetylation of Carbohydrates¡§ Chem. Asian J. 2017, 12, 2471-2479.

 

Cooperation:

1. Ting-Chun Kuan, Hsin-Ru Wu, Avijit K. Adak, Ben-Yuan Li, Chien-Fu Liang, Jung-Tung Hung, Shih-Pin Chiou, Alice L. Yu, Jih Ru Hwu, Chun-Cheng Lin* ¡§Synthesis of an S-Linked £\(2¡÷8) GD3 Antigen and Evaluation of the Immunogenicity of Its Glycoconjugate¡¨ Chem. Eur. J. 2017, 23, 6876-6887.

2. Heung-Sik Hahm, Chien-Fu Liang, Chian-Hui Lai, Richard J. Fair, Peter H. Seeberger* ¡§Automated Glycan Assembly of Complex Oligosaccharide Related to Blood Group Determinants¡¨ J. Org. Chem. 2016, 81, 5866-5877.

3. Wei-Ting Chien, Chien-Fu Liang, Ching-Ching Yu, Chien-Hung Lin, Si-Peng Li, Kuo-Chu Hwang, Indah Primadona, Yu-Ju Chen, Chun-Cheng Lin* ¡§Sequential one-pot enzymatic synthesis of oligo-N-acetyllactosamine and its multi-sialylated extensions¡¨ Chem. Commun. 2014, 50, 5786-5789.

4. Shiao-Chan Wang, Ching-Ching Yu, Chien-Fu Liang, Li-De Huang, Jih-Ru Hwu, Chun-Cheng Lin* ¡§Site-selective protein immobilization via 2-cyanobenzothiazole cysteine condensation¡¨ ChemBioChem, 2014, 15, 829-835.

5. Wei-Ting Chien, Chien-Fu Liang, Ching-Ching Yu, Jian- Hong Lin, Haung-Ting Wu, Chun-Cheng Lin* ¡§Glucose-1-phosphate Thymidylyltransferasein the Synthesis of Uridine 5'-DiphosphateGalactose and its Application on Synthesis of N-Acetyllactosamine ¡¨Adv. Synth. Catal. 2012, 354, 123-132.

Book Chapter:

1. Chien-Fu Liang, Heung Sik Hahm, and Peter H. Seeberger*; ¡¥¡¦ Automated Synthesis of Chondroitin Sulfate Oligosaccharides ¡¦¡¦ Methods in Molecular Biology (Clifton, N.J.), 2015, Volume 1229, Chapter 1, 3-10.

2. Wei-Ting Chien, Ching-Ching Yu, Chien-Fu Liang, Chian-Hui, Lai, Po-Chiao  Lin, and Chun-Cheng Lin*; Functional Glyconanoparticles for the Study of Glycobiology Petite and Sweet: Glyco-Nanotechnology as a Bridge to New Medicine, ACS Symposium Series, 2011, Volume 1091, Chapter 2, 15-36.

Awards/Honors/Fellowships:

1. 109¾Ç¦~«×¤¤¿³¤j¾Ç±Ð¾Ç¯SÀuII

2. 111¾Ç¦~«×¤¤¿³¤j¾ÇÀu¸u±Ð®vIII

3. Max Planck research fellowship, Max Planck Institute, Berlin, Germany, 2012-2014.

4. Academic published award of postdoctoral researchers, National Science Council, Taiwan, 2013 (°ê¬ì·|³Õ¤h«á¬ã¨s¤H­û¾Ç³NµÛ§@¼ú).

5. The Outstanding PhD Thesis Award of Chinese Chemistry Society, 2009 (¤¤°ê¤Æ¾Ç¾Ç·|³Õ¤h½×¤å³Ç¥X¼ú-¦³¾÷¤Æ¾Ç²Õ).

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