E-mail : lcf0201@dragon.nchu.edu.tw

Tel : (04)-22840411-ext 701

梁健夫
Chien-Fu Liang

有機化學暨生物有機

(Organic & Bioorganic Lab)

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l   Associate Professor, National Chung Hsing University (2019-)

l   Assistant Professor, National Chung Hsing University (2015-2019)

l   Postdoctoral research fellow: National Sun Yat-sen University, (2014.11~2015.7)

l   Postdoctoral research fellow: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. (2012.11~2014.10)

l   Postdoctoral research fellow: National Tsing Hua University (2010.10~2012.9)

l   PhD National Tsing Hua University (2005.9-2009.7)

l   M.S. National Tsing Hua University (2003.9-2005.7)

l   B.S. National Chung Hsing University (2000.9 – 2003.6)

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1.  利用金屬催化來合成重要及有趣的有機化合物。

2.  開發新穎有機反應並著重於水相化學鍵結方法，進而應用於生物分子之修飾。

3. 化學生物學:利用有機合成的觀念來設計功能化分子以及複雜寡醣抗原，進而研究重要的生物作用。

 

1.  Using metal catalysts to synthesize important and interesting organic molecules.

2.  Development of organic methodology: With particular interest in aqueous reaction systems for application in site-selective chemical modification of biomolecules

3.  Chemical Biology: Use the concept of organic chemistry to design the functional probes and the synthesis of complex carbohydrate antigens, to study the biomolecular interaction.

 

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Articles :

First author or corresponding author:

1. Hsin-Yi, Huang, Chien-Fu Liang* “ Sequential Ytterbium(III) Triflate Catalyzed One-Pot Three-Component Thia-Michael Addition” Asian J. Org. Chem. 2018, 7, 955-963.

2. Yen-Sen, Liao, Chien-Fu Liang* “One-Pot Synthesis of Thioester with Sodium Thiosulfate as a Sulfur Surrogate under Transition Metal-Free Conditions” Org. Biomol. Chem. 2018, 16, 1871-1881.

3. Jiun-Rung Guo, Hsin-Yi Huang, Yi-Ling Yan, Chien-Fu Liang* “Selective S-Deacetylation of Functionalized Thioacetates Catalyzed by Dy(OTf)3” Asian J. Org. Chem. 2018, 7, 179-188.

4. Yi-Ling Yan, Jiun-Rung Guo, Chien-Fu Liang* “Sequential Dy(OTf)3-Catalyzed Solvent-Free Per-O-Acetylation and Regioselective Anomeric De-O-Acetylation of Carbohydrates“ Chem. Asian J. 2017, 12, 2471-2479.

5. Ying-Yu Chen, Kuan-Lin Chen, Chien-Fu Liang*, Po-Chiao Lin* “Synthesis of Substituted 3-methylene-2,3-dihydrobenzofurans and 3-methylbenzofurans by Rhodium (II)-Catalyzed Annulation” Tetrahedron 2015, 71, 6210-6218. (IF:2.651)

6. Chien-Fu Liang, Ting-Chun Kuan, Tsung-Che Chang, Chun-Cheng Lin* ‘’Stereoselective Synthesis of S-linked α(2→8) and α(2→8)/α(2→9) Hexasialic Acids’’ J. Am. Chem. Soc.2012, 134, 16074-16079.

7. Chien-Fu Liang, Ming-Chung Yan, Tsung-Che Chang, Chun-Cheng Lin* “Synthesis of S-Linked α(2→9) Octasialic Acid via Exclusive α S-Glycosidic Bond Formation”J. Am. Chem. Soc. 2009, 131, 3138-3139.

 

Cooperation:

1. Ting-Chun Kuan, Hsin-Ru Wu, Avijit K. Adak, Ben-Yuan Li, Chien-Fu Liang, Jung-Tung Hung, Shih-Pin Chiou, Alice L. Yu, Jih Ru Hwu, Chun-Cheng Lin* “Synthesis of an S-Linked α(2→8) GD3 Antigen and Evaluation of the Immunogenicity of Its Glycoconjugate” Chem. Eur. J. 2017, 23, 6876-6887.

2. Heung-Sik Hahm, Chien-Fu Liang, Chian-Hui Lai, Richard J. Fair, Peter H. Seeberger* “Automated Glycan Assembly of Complex Oligosaccharide Related to Blood Group Determinants” J. Org. Chem. 2016, 81, 5866-5877.

3. Wei-Ting Chien, Chien-Fu Liang, Ching-Ching Yu, Chien-Hung Lin, Si-Peng Li, Kuo-Chu Hwang, Indah Primadona, Yu-Ju Chen, Chun-Cheng Lin* “Sequential one-pot enzymatic synthesis of oligo-N-acetyllactosamine and its multi-sialylated extensions” Chem. Commun. 2014, 50, 5786-5789.

4. Shiao-Chan Wang, Ching-Ching Yu, Chien-Fu Liang, Li-De Huang, Jih-Ru Hwu, Chun-Cheng Lin* “Site-selective protein immobilization via 2-cyanobenzothiazole cysteine condensation” ChemBioChem, 2014, 15, 829-835.

5. Wei-Ting Chien, Chien-Fu Liang, Ching-Ching Yu, Jian- Hong Lin, Haung-Ting Wu, Chun-Cheng Lin* “Glucose-1-phosphate Thymidylyltransferasein the Synthesis of Uridine 5'-DiphosphateGalactose and its Application on Synthesis of N-Acetyllactosamine”Adv. Synth. Catal. 2012, 354, 123-132.

 

Book Chapter:

1. Chien-Fu Liang, Heung Sik Hahm, and Peter H. Seeberger*; ‘’ Automated Synthesis of Chondroitin Sulfate Oligosaccharides ’’ Methods in Molecular Biology (Clifton, N.J.), 2015, Volume 1229, Chapter 1, 3-10.

2. Wei-Ting Chien, Ching-Ching Yu, Chien-Fu Liang, Chian-Hui, Lai, Po-Chiao Lin, and Chun-Cheng Lin*; Functional Glyconanoparticles for the Study of Glycobiology Petite and Sweet: Glyco-Nanotechnology as a Bridge to New Medicine, ACS Symposium Series, 2011, Volume 1091, Chapter 2, 15-36.

 

Awards/Honors/Fellowships:

1. Max Planck research fellowship, Max Planck Institute, Berlin, Germany, 2012-2014.

2. Academic published award of postdoctoral researchers, National Science Council, Taiwan, 2013 (國科會博士後研究人員學術著作獎).

3. The Outstanding PhD Thesis Award of Chinese Chemistry Society, 2009 (中國化學學會博士論文傑出獎-有機化學組).

4. Eli Lilly Asia Outstanding Graduate Thesis Award (Lilly USA, LLC Scholarship, 2009, Shanghai, China).

 

Selected Conferences:

1.  Dysprosium(III) Triflate-Catalyzed Solvent-Free Per-O-Acetylation and Anomeric De-O(S)-Acetylation of Carbohydrates. 29th International Carbohydrate Symposium, 2018, Lisbon, Portugal. (Poster)

2.  Efficient Automated Synthesis of Chondroitin Sulfate D Related Dimer to Oligomer. Max Planck Institute of Colloids and Interfaces Conference, 2014, Rottach-Egern, Germany. (Oral Presentation)

3.  Synthesis of S-linked α(2→8) and α(2→8)/α(2→9) Hexasialic Acids via S-alkylation. 16th European Carbohydrate Symposium, 2011, Sorrento, Italy (Poster)

4.  Synthesis of S-linkedα(2→9) octa-sialic acid with Exclusive α S-glycosidic Bond Formation 15th European Carbohydrate Symposium, 2009, Vienna, Austria. (Poster)

 

國立中興大學化學系National Chung Hsing University Department of Chemistry

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