賴建成 教授 Chien-Chen Lai                   BACK




台灣大學博士
個人網頁
http://web.nchu.edu.tw/~lailai/
lailai@dragon.nchu.edu.tw
辦公室電話: 04-22840485#235
實驗室電話: 04-22840485#236

簡要經歷
 
學歷

Ph. D., Analytical Chemistry
National Taiwan University, Taipei, Taiwan (Dissertation Advisor: Prof. Guor-Rong Her 何國榮)
Dissertation Title: Analysis of Single Bee Venom by Mass Spectrometry.

M.S., Analytical Biochemistry and Physical Biochemistry
National Taiwan University, Taipei, Taiwan (Thesis Advisor: Prof. T. I. Lin 林宗義)

B. S., Chemistry
National Taiwan University, Taipei, Taiwan

經歷

中興大學特聘教授 (2012/08~迄今)

台灣質譜學會常務理事 (2012/07~迄今).
Standing Director and Member of Taiwan Society for Mass Spectrometry (TSMS).

台灣質譜學會理事 (2003/07-2012/06).
Director and Member of Taiwan Society for Mass Spectrometry (TSMS).

台灣蛋白體學會理事 (2008/12-迄今)
Director and Member of Taiwan Proteomics Society.

台灣質譜學會秘書長 (2006/07-2009/07)
Secretary-General of Taiwan Society for Mass Spectrometry. (TSMS)

中興大學生物科技發展中心推廣服務組組長
Head for Service Division, Biotechnology Center, NCHU, Taichung, Taiwan.

中興大學分子生物學研究所副教授
Associate Pofessor, Institute of Molecular Biology, NCHU.

中興大學分子生物學研究所助理教授
Asistant Pofessor, Institute of Molecular Biology, NCHU.

中國醫藥大學中醫所兼任教授

中國醫藥大學中醫所兼任副教授

中國醫藥大學附設醫院醫學研究部研究員
Researcher, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

中國醫藥大學附設醫院醫學研究部副研究員
Associate Researcher, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

美國質譜學會會員 (2002-迄今)
Member of American Society for Mass Spectrometry

人類遺傳學會會員
Member of Taiwan Human Genetics Society

中國化學會永久會員
Permanent Member of Chinese Chemical Society


研究方向
 


* 質譜術 (Mass Spectrometry)
* 生化分析 (Analytical Biochemistry)
* 蛋白質體學 (Proteomics)
* 臨床篩檢 (Clinical Screening)
* 儀器分析 (Instrumental Analysis)
* 臨床化學 (Clinical Chemistry)

參與之研究計劃

個人主持計劃

  1. Application of Mass Spectrometry in Nanomaterials, Proteomics and Metabolomics (質譜術於奈米材料、蛋白質體學與代謝體學之應用) (國科會102-2113-M-005-001-MY3) 計畫主持人:賴建成 2013.08.01 to 2016.07.31
  2. Develop an analytical platform for efficient detection of biomolecules using electron transfer dissociation technique and mass spectrometry (利用電子轉移裂解技術與質譜術發展高效率之生化分子分析平台) (國科會99-2113-M-005-001-MY3) 計畫主持人:賴建成 2010.08.01 to 2013.07.31
  3. Develop an analytical platform for efficient detection of rice proteome and phosphoproteome using electron transfer dissociation technique and mass spectrometry (利用電子轉移裂解技術與質譜術發展高效率之水稻蛋白質體與磷酸蛋白質體分析平台) (國科會96-2113-M-005-011-MY3) 計畫主持人:賴建成 2007.08.01 to 2010.07.31
  4. Diagnostic Screening for Mucopolysaccharidoses by Mass Spectrometry (黏多醣貯積症之篩選診斷法:質譜檢驗方法開發) (國科會95-2113-M-005-023-) 計畫主持人:賴建成 2006.08.01 to 2007.07.31
  5. Development of a rapid screening assay for alkaptonuria, urea cycle disorders and neuroblastoma (II) (以質譜術快速篩檢黑尿症,尿素循環疾病及神經母細胞瘤之技術建立 (II)) (國科會94-2113-M-039-002-) 計畫主持人:賴建成 2005.08.01 to 2006.07.31
  6. Development of a rapid screening assay for alkaptonuria, urea cycle disorders and neuroblastoma (以質譜術快速篩檢黑尿症,尿素循環疾病及神經母細胞瘤之技術建立) (國科會93-2113-M-039-001-) 計畫主持人:賴建成 2004.08.01 to 2005.07.31
  7. A rapid screening assay for measuring very long chain fatty acids from newborns with congenital peroximal disorders by liquid chromatography/tandem mass spectrometry (2/2) (液相層析/串聯質譜儀連線偵測極長鏈脂肪酸於新生兒之先天性過氧化?體失調之篩選應用(2/2)) (國科會92-2113-M-039-003-) 計畫主持人:賴建成 2003.08.01 to 2004.07.31
  8. 以液相層析/串聯式質譜儀建立別嘌醇測試法(allopurinol test)及罕見疾病戊二酸尿症第一型的生化與分子醫學診斷 (行政院衛生署國民健康局) 計畫主持人:賴建成 2003.01.01 to 2004.12.31
  9. A rapid screening assay for measuring very long chain fatty acids from newborns with congenital peroximal disorders by liquid chromatography/tandem mass spectrometry (1/2) (液相層析/串聯質譜儀連線偵測極長鏈脂肪酸於新生兒之先天性過氧化?體失調之篩選應用(1/2)) (國科會91-2113-M-039-001-) 計畫主持人:賴建成 2002.08.01 to 2003.07.31
  10. A rapid screening assay for measuring steroid hormone in dried blood specimens from newborns with congenital adrenal hyperplasia by liquid chromatography/tandem mass spectrometry (液相層析/串聯質譜儀連線偵測類固醇荷爾蒙於新生兒之先天性腎上腺增生症之篩選應用) (國科會90-2113-M-039-002-) 計畫主持人:賴建成2001.08.01 to 2002.07.31
  11. Rapid Assay of Dehydroepiandrosterone and Its Sulfate levels in Patients with Thyroid Dysfunction and Growth Hormone Deficiency using High Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry (液相層析/質譜儀連線於甲狀腺功能不全與成長激素缺乏症病人血液中Dehydroepiandrosterone及其硫酸鹽之快速偵測) (中國醫藥學院附設醫院院內計劃DMR-91-101) 計畫主持人:賴建成2001.08.01 to 2002.07.31

個人共同主持計劃

  1. 腸病毒71型5端非轉譯區之抗病毒中藥活性分析與機轉探討 (國科會 100-2320-B-039-012-MY3), 2011.08.01 to 2014.07.31
  2. 與第二型蛋白分泌機器 ATPase 具專一性結合作用之膜蛋白 GspL 中之專一性決定因子(國科會97-2311-B-005-005-MY3), 2008.08.01 to 2011.07.31
  3. 綠豆澱粉磷解〞滌穧]選殖、表現與生化特性探討(國科會97-2313-B-019-011-MY3), 2008.08.01 to 2012.02.29
  4. 以系統生物分析技術探索SARS冠狀病毒蛋白脢PLpro及3CLpro對ubiquitin訊息傳遞機制之影響(國科會96-2320-B-039-008-MY3),2007.08.01 to 2010.07.31
  5. SARS冠狀病毒蛋白?3CLpro與PLpro之分子致病機制探討:細胞週期、細胞凋亡及發炎訊號(國科會95-2320-B-039-019-),2006.08.01 to 2007.07.31
  6. 誘發大白鼠草酸鈣結石腎臟蛋白質改變的質譜儀特性研究(國科會95-2314-B-039-016-),2006.08.01 to 2007.07.31
  7. 人類結石之蛋白質體研究:偵測台灣地區結石之生物標誌及其病因(國科會94-2320-B-039-036-),2005.08.01 to 2006.07.31
  8. D型安非他命對培養的人類肝臟及白血球細胞誘發基因蛋白質體表現變異及細胞凋亡之探討,(衛生署管制藥品管理局) 2002.01.01 to 2002.12.31

實驗室概況

本實驗室的研究發展重點主要是利用質譜術配合各式樣品前處理技術與分離技術進行各項研究, 藉由液相層析串聯質譜儀 (LC/MS/MS) 與基質輔助雷射脫附-飛行時間式質譜儀 (MALDI-TOFMS) 的特性發展應用於 蛋白質體學、代謝體學及臨床醫學等定性與定量之研究。

研究興趣

  1. 以質譜為基礎,改良及開發定性與定量之蛋白質體技術,藉此尋找並深入探討生物標記分子。

  2. 改良及開發各種蛋白質轉譯後修飾之質譜偵測技術,並藉此深入探討生理機轉。

  3. 以質譜術快速篩檢代謝體學相關有機小分子之技術建立,並應用於動植物體內代謝之機制分析。

  4. 質譜為基礎之臨床醫學研究。


近期著作
 


  1. W. Y. Hsu, C. J. Chen, Y. H. Huang, C. C. Lai*, F. J. Tsai*, 2013, Urinary nucleosides as biomarkers of breast, colon, lung, and gastric cancer in Taiwanese. Plos One, in press. SCI (IF: 3.73)

  2. Y. M. Juang, T. F. She, H. Y. Chen, C. C. Lai*, 2013, Comparison of CID Versus ETD-based MS/MS Fragmentation for the Analysis of Doubly Derivatized Steroids. J. Mass Spec., in press. SCI (IF:3.214)

  3. W. Y. Hsu, C. M. Chen, F. J. Tsai*, C. C. Lai*, 2013, Simultaneous detection of diagnostic biomarkers of alkaptonuria, ornithine carbamoyltransferase deficiency, and neuroblastoma disease by high-performance liquid chromatography/tandem mass spectrometry. Clin Chim Acta., 420, 140-145. SCI (IF: 2.535)

  4. Y. J. Lin, C. C. Lai, C. H. Lai, S. C. Sue, C. W. Lin, C. H. Hung, T. H. Lin, W. Y. Hsu, S. M. Huang, Y. L. Hung, N. Tien, X. Liu, C. L. Chen, F. J. Tsai*. 2013, Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide. Eur. J. Med. Chem., 62C, 206-213. SCI (IF: 3.346)

  5. H. J. Lin#, C. C. Lai#, S. Y. Huang, W. Y. Hsu, F. J. Tsai*. 2013, An Increase in Phosphorylation and Truncation of Crystallin With the Progression of Cataracts. Current Therapeutic Research., 74, 9-15. SCI (IF: 0.446)

  6. B. Kaziowski, M. R. Chen, P. M. Chao, C. C. Lai*, Y. T. Ko*. 2013, Identification and the roles of proteins for seed development in mungbean (Vigna radiata L.) seed proteomes. J. Agric. Food Chem., in press. SCI (IF: 2.823)

  7. C. J. Chen*, C. C. Lai, M. C. Tseng, Y. C. Liu, S. Y. Lin, F. J. Tsai*, 2013, Simple fabrication of hydrophobic surface target for increased sensitivity and homogeneity in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of peptides, phosphopeptides, carbohydrates and proteins. Anal. Chim. Acta., 783, 31-38. SCI (IF :4.387)

  8. Y. H. Lin, C. C. Lai, Y. H. Liu, S. M. Peng, S. H. Chiu*, 2013, Sodium Ions Template the Formation of Rotaxanes from BPX26C6 and Nonconjugated Amide and Urea Functionalities. Angew. Chem. Int. Ed. Engl., in press. SCI (IF: 13.455)

  9. P. Kanjanaphachoat, B. Y. Wei, S. F. Lo, I. W. Wang, C. S. Wang, S. M. Yu, M. L. Yen, S. H. Chiu, C. C. Lai*, L. J. Chen*. 2012, Serotonin accumulation in transgenic rice by over-expressing tryptophan decarboxlyase results in a dark brown phenotype and stunted growth. Plant Mol Biol, 78(6), 525-543. SCI (IF: 4.15)

  10. S. W. Li, T. C. Yang, L. Wan, Y. J. Lin, F. J. Tsai, C. C. Lai*, C. W. Lin*, 2012, Correlation between TGF beta-1 expression and proteomic profiling induced by SARS coronavirus papain like-protease. Proteomics, 12(21), 3193-3205. SCI (IF: 4.505,)

  11. C. W. Liu, M. W. Chien, C. Y. Su, H. Y. Chen, L. J. Li*, C. C. Lai*, 2012, Analysis of flavonoids by graphene-based surface-assisted laser desorption/ionization time-of-flight mass spectrometry. Analyst, 137(24), 5809-5816. SCI (IF: 4.23)

  12. C. W. Liu, Y. K. Hsu, Y. H. Cheng, H. C. Yen, Y. P. Wu, C. S. Wang*, C. C. Lai*, 2012, Proteomic analysis of salt-responsive ubiquitin-related proteins in rice roots, Rapid Commu. Mass Spectrom. 26(15), 1649-1660. SCI, 2012 Aug 15 (IF: 2.79)

  13. J. H. Lai, T. F. She, Y. M. Juang, Y. G. Tsay, J. J. W. Chen*, C. C. Lai*, 2012, Comparative Proteomic Profiling of Human Lung Adenocarcinoma Cells (CL 1-0) Expressing miR-372. Electrophoresis, 33(4), 675-688. SCI (IF: 3.569)

  14. W. Y. Hsu, V. S. Wang, C. C. Lai*, F. J. Tsai*, 2012, Simultaneous Determination of Components Released from Dental Composite Resins in Human Saliva by Liquid Chromatography/Multiple-Stage Ion Trap Mass Spectrometry. Electrophoresis, 33(4), 719-725. SCI (IF: 3.569)

  15. Y. Wang, Q. Ding, C. J. Yen, W. Xia, J. G. Izzo, J. Y. Lang, C. W. Li, J. L. Hsu, S. A. Miller, X. Wang, D. F. Lee, J. M. Hsu, L. Huo, A. M. Labaff, D. Liu, T. H. Huang, C. C. Lai, F. J. Tsai, W. C. Chang, C. H. Chen, T. T. Wu, N. S. Buttar, K. K. Wang, Y. Wu, H. Wang, J. Ajani, M. C. Hung*, 2012, The Crosstalk of mTOR/S6K1 and Hedgehog Pathways. Cancer Cell, 21(3), 374-387. SCI (IF: 26.566)

  16. V. S. Wang, T. Y. Chang, C. C. Lai, S. Y. Chen, L. C. Huang, K. P. Chao, 2012, Application of solid phase microextraction on dental composite resin analysis. J. Chromatogr B. 903, 88-94. SCI (IF=2.888)

  17. C. F. Chang, C. J. Chuang, C. C. Lai, Y. H. Liu, S. M. Peng*, S. H. Chiu*, 2012, Using host-guest complexation to fold a flexible linear organic string: kinetically controlled syntheses of [3]catenanes and a five-membered molecular necklace. Angew. Chem. Int. Ed. Engl., 51(40), 10094-10098. SCI (IF: 13.455)

  18. C. W. Liu, M. W. Chien, S. Y. Chen, C. S. Yu, M. Y. Liao*, C. C. Lai*, 2011, Quantum Dots Enhance Peptide Detection by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. Anal. Chem., 83(17), 6593-6600. SCI (IF: 5.874)

  19. S. Y. Chen, Y. M. Juang, M. W. Chien, K. I. Li, C. S. Yu, C. C. Lai*, 2011, Magnetic Iron Oxide Nanoparticle Enrichment of Phosphopeptides on a Radiate Microstructure MALDI Chip. Analyst, 136(21), 4454-4459. SCI (IF: 3.913)

  20. W. Y. Hsu, W. D. Lin, Y. Tsai, C. T. Lin, H. C. Wang, L. B. Jeng, C. C. Lee, Y. C. Lin, C. C. Lai*, F. J. Tsai*, 2011, Analysis of Urinary Nucleosides as Potential Tumor Markers in Human Breast Cancer by High Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry. Clin Chim Acta., 412(19-20), 1861-1866. SCI (IF: 2.389)

  21. Y. M. Juang, C. J. Chen, C. C. Lai*, 2011, Conductive Carbon Tape as A Sample Platform for Microwave-Based MALDI MS Detection of Proteins and Phosphoproteins. Anal. Bioanal. Chem. 401(4), 1219-1229. SCI (IF: 3.841)

  22. C. W. Liu, C. C. Lai*, 2011, Effects of Electron-Transfer Coupled with Collision Induced Dissociation (ET/CID) on Doubly-Charged Peptides and Phosphopeptides. J. Am. Soc. Mass Spectrom., 22(1), 57-66. SCI (IF: 3.83)

  23. S. W. Li, C. C. Lai*, J. F. Ping, F. J. Tsai, L. Wan, Y. J. Lin, S. H. Kung, C. W. Lin*, 2011, SARS Coronavirus Papain-Like Protease Suppressed Interferon-{alpha}-Induced Responses Through Down-Regulation of ERK1-Mediated Signaling Pathways. J. Gen. Virol., 92(Pt5), 1127-1140. SCI (IF: 3.568)

  24. J. M. Hsu, C. T. Chen, C. K. Chou, H. P. Kuo, L. Y. Li, C. Y. Lin, H. J. Lee, Y. N. Wang, M. Liu, H. W. Liao, B. Shi, C. C. Lai, M. T. Bedford, C. H. Tsai, M. C. Hung*, 2011, Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat. Cell Biol. 13(2), 174-181. SCI (IF: 19.407)

  25. R. Zhao, S. C. Yeung, J. Chen, T. Iwakuma, C. H. Su, B. Chen, C. Qu, F. Zhang, Y. T. Chen, Y. L. Lin, D. F. Lee, F. Jin, R. Zhu, T. Shaikenov, D. Sarbassov, A. Sahin, H. Wang, H. Wang, C. C. Lai, F. J. Tsai, G. Lozano, M. H. Lee*. 2011, Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J. Clin. Invest., 121(3), 851-65. (IF 14.152)

  26. Y. Wei, Y. H. Chen, L. Y. Li, J. Lang, S. P. Yeh, B. Shi, C. C. Yang, J. Y. Yang, C. Y. Lin, C. C. Lai, M. C. Hung*, 2011, CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat. Cell Biol. 13(1), 87-94. SCI (IF: 19.407)

  27. L. Y. Li, H. Chen, Y. H. Hsieh, Y. N. Wang, H. J. Chu, Y. H. Chen, H. Y. Chen, P. J. Chien, H. T. Ma, H. C. Tsai, C. C. Lai, Y. P. Sher, H. C. Lien, C. H. Tsai, M. C. Hung*. 2011, Nuclear ErbB-2 Enhances Translation and Cell Growth by Activation of rRNA Gene Transcription. Cancer Res., 71(12), 4269-4279. (IF: 8.234)

  28. P. N. Chen, C. C. Lai, S. H. Chiu*, 2011, Self-sorting under solvent-free conditions: one-pot synthesis of a hetero[3]rotaxane. Org. Lett., 13(17), 4660-4663. SCI (IF: 5.25)

  29. S. Y. Hsueh, J. L. Ko, C. C. Lai, Y. H. Liu, S. M. Peng, S. H. Chiu*. 2011, A Metal-Free "Threading-Followed-by-Shrinking" Protocol for Rotaxane Synthesis. Angew. Chem. Int. Ed. Engl., 50(29), 6643-6646. SCI (IF: 12.73)

  30. B. Y. Wei, Y. M. Juang, C. C. Lai*, 2010, A Novel Approach for Quantitative Peptides Analysis by Selected Electron Transfer Reaction Monitoring. J. Chromatogr. A, 1217(44), 6927-6931. SCI (IF: 4.194)

  31. S. Y. Chen, K. I. Li, C. S. Yu, J. S. Wang, Y. C. Hu*, C. C. Lai*, 2010, A Radiate Microstructure MALDI Chip for Sample Concentration and Detection. Anal. Chem., 82(14), 5951-5957. SCI (IF: 5.874)

  32. W. Y. Hsu, W. D. Lin, W. L. Hwu, C. C. Lai*, F. J. Tsai*, 2010, Screening assay of very long chain Fatty acids in human plasma with multiwalled carbon nanotube-based surface-assisted laser desorption/ionization mass spectrometry. Anal. Chem., 82(16), 6814-6820. SCI (IF: 5.874)

  33. Y. M. Juang, C. Y. Lee, W. Y. Hsu, C. T. Lin, C. C. Lai*, F. J. Tsai*, 2010, Proteomic analysis of chondrocytes exposed to pressure. Biomed Chromatogr, 24(12), 1273-1282. SCI (IF: 1.545)

  34. P. C. Chang#, J. N. Sudhakar#, C. C. Lai (Co-first author)#, H. C. Chen*, 2010, Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions. Oncogene, 29(5), 698-710. SCI (IF: 7.414)

  35. S. Y. Hsueh, C. T. Kuo, T. W. Lu, C. C. Lai, Y. H. Liu, H. F. Hsu, S. M. Peng, C. H. Chen, S. H. Chiu*, 2010, Acid/base- and anion-controllable organogels formed from a urea-based molecular switch. Angew. Chem. Int. Ed. Engl., 49(48), 9170-9173. SCI (IF: 12.73)

  36. L. Huo, Y. N. Wang, W. Xia, S. C. Hsu, C. C. Lai, L. Y. Li, W. C. Chang, Y. Wang, M. C. Hsu, Y. L. Yu, T. H. Huang, Q Ding, C. H. Chen, C. H. Tsai, M. C. Hung*, 2010, RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc Natl Acad Sci U S A., 107(37), 16125-16130. SCI (IF: 9.771)

  37. T. C. Yang, C. C. Lai, S. L. Shiu, P. H. Chuang, B. C. Tzou, Y. Y. Lin, F. J. Tsai, C. W. Lin, 2010, Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells. Microbes. Infect., 12(8-9), 643-651. (IF: 2.726)

  38. S. Y. Hsueh, C. C. Lai, S. H. Chiu*, 2010, Squaraine-Based [2]Rotaxanes that Function as Visibly Active Molecular Switches. Chemistry : a European Journal., 16(10), 2997-3000. SCI (IF: 5.476)

  39. W. Y. Hsu, T. L. Chen, W. D. Lin, F. J. Tsai, Y. Tsai, C. T. Lin, W. Y. Lo, L. B. Jeng*, C. C. Lai*, 2009, Analysis of urinary nucleosides as potential tumor markers in human colorectal cancer by high performance liquid chromatography/electrospray ionization tandem mass spectrometry. Clin Chim Acta., 402(1-2), 31-37. SCI (IF: 2.389)
  40. D. F. Lee, H. P. Kuo, M. Liu, C. K. Chou, W. Xia, Y. Du, J. Shen, C. T. Chen, L. Huo, M. C. Hsu, C. W. Li, Q. Ding, T. L. Liao, C. C. Lai, A. C. Lin, Y. H. Chang, S. F. Tsai, L. Y. Li, M. C. Hung*, 2009, KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell, 36(1), 131-140. SCI (IF: 14.194)
  41. C. C. Chen, Y. C. Cho, C. C. Lai, W. H. Hsu*, 2009, Purification and characterization of a new Rhizopuspepsin from Rhizopus oryzae NBRC 4749. J. Agric. Food Chem., 57(15), 6742-6747. SCI (IF: 2.816)
  42. M. J. Li, C. C. Lai, Y. H. Liu, S. M. Peng, S. H. Chiu*, 2009, Two guest complexation modes in a cyclotriveratrylene-based molecular container. Chem Commun (Camb)., 39, 5814-5816. SCI (IF: 5.787)
  43. T. C. Lin, C. C. Lai, S. H. Chiu*, 2009, A guanidinium ion-based anion- and solvent polarity-controllable molecular switch. Org. Lett., 11(3), 613-616. SCI (IF: 5.25)
  44. P. T. Chiang, N. C. Chen, C. C. Lai*, S. H. Chiu*, 2008, Direct observation of mixed-valence and radical cation dimer States of tetrathiafulvalene in solution at room temperature: association and dissociation of molecular clip dimers under oxidative control. Chemistry : a European Journal., 14(21), 6546-6552 SCI (IF: 5.476)
  45. J. L. Su, P. S. Chen, M. H. Chien, P. B. Chen, Y. H. Chen, C. C. Lai, M. C. Hung, M. L. Kuo, 2008, Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells. Cancer Cell, 13(6), 557-560. SCI (IF: 26.925)
  46. C. C. Hsu, N. C. Chen, C. C. Lai, Y. H. Liu, S. M. Peng, S. H. Chiu*, 2008, Solvent-free synthesis of the smallest rotaxane prepared to date. Angew. Chem. Int. Ed. Engl., 47(39), 7475-7478. SCI (IF: 12.73)
  47. S. Y. Hsueh, K. W. Cheng, C. C. Lai, S. H. Chiu*, 2008, Efficient solvent-free syntheses of [2]- and [4]rotaxanes, Angew. Chem. Int. Ed. Engl., 47(23), 4436-4439. SCI (IF: 12.73)
  48. W. C. Chen, C. C. Lai, Y. H. Tsai, W. Y. Lin, F. J. Tsai, 2008, Mass spectroscopic characteristics of low molecular weight proteins extracted from calcium oxalate stones: preliminary study. J. Clin. Lab Anal. 22, 77-85. SCI. (IF: 1.031)
  49. N. C. Chen, C. C. Lai, Y. H. Liu, S. M. Peng, S. H. Chiu, 2008, Parking and Restarting a Molecular Shuttle In Situ. Chemistry : a European Journal., 14(9), 2904-2908. SCI (IF: 5.476)
  50. J. Y. Yang, C. S. Zong, W. Xia, H. Yamaguchi, Q. Ding, X. Xie, J. Y. Lang, C. C. Lai, C. J. Chang, W. C. Huang, H. Huang, H. P. Kuo, D. F. Lee, L. Y. Li, H. C. Lien, X. Cheng, K. J. Chang, C. D. Hsiao, F. J. Tsai, C. H. Tsai, A. A. Sahin, W. J. Muller, G. B. Mills, D. Yu, G. N. Hortobagyi, M. C. Hung, 2008, ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat. Cell Biol., 10, 138-148. SCI (IF: 19.407)
  51. Q. Ding, L. Huo, J. Y. Yang, W. Xia, Y. Wei, Y. Liao, C. J. Chang, Y. Yang, C. C. Lai, D. F. Lee, C. J. Yen, Y. J. Chen, J. M. Hsu, H. P. Kuo, C. Y. Lin, F. J. Tsai, L. Y. Li, C. H. Tsai, M. C. Hung*, 2008, Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Res., 68(15), 6109-6117. (IF: 8.234)
  52. W. Y. Hsu, W. Y. Lo, C. C. Lai*, F. J. Tsai*, C. H. Tsai, Y. Tsai, W. D. Lin and M. C. Chao, 2007, Rapid Screening Assay of Trimethylaminuria with Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry in Urine. Rapid Commu. Mass Spectrom., 21, 1915-1919. SCI (IF: 2.846)
  53. W. Y. Lo, M. H. Tsai, Y. Tsai, C. H. Hua, F. J. Tsai, S. Y. Huang, C. H. Tsai, C. C. Lai*, 2007, Identification of Over-expressed Proteins in Oral Squamous Cell Carcinoma (OSCC) patients by Clinical Proteomic Analysis. Clin Chim Acta., 376, 101-107. SCI (IF: 2.389)
  54. C. C. Lai, M. J. Jou, S. Y. Huang, S. W. Li, L. Wan, F. J. Tsai, C. W. Lin, 2007, Proteomic Analysis of Up-regulated Proteins in Human Promonocyte Cells Expressing SARS Coronavirus 3C-Like Protease. Proteomics, 7, 1446-1460. SCI (IF: 5.074)
  55. W. Y. Lo, C. C. Lai (Co-first author), C. H. Hua, M. H. Tsai, S. Y. Huang, C. H. Tsai, F. J. Tsai, 2007, S100A8 is identified as a biomarker of HPV18 infected oral squamous cell carcinomas by suppression subtraction hybridization, clinical proteomics analysis and immunohistochemistry staining. J. Proteome. Res. 6, 2143-2151. (IF: 5.46)
  56. 許维儀、賴建成*、蔡輔仁、林瑋德, 2007, 質譜術於臨床代謝體學之應用. Chemistry (The Chinese Chemical Society, Taipei), 65, 169-185.
  57. D. F. Lee, H. P. Kuo, C. T. Chen, J. M. Hsu, H. L. Sun, C. K. Chou, Y. Wei, L. Y. Li, B. Ping, W. C. Huang, X. He, J.Y. Hung, C. C. Lai, Q. Ding, J. L. Su, J. Y. Yang, A. A. Sahin, G. N. Hortobagyi, F. J. Tsai, C. H. Tsai, and M. C. Hung, 2007, Suppression of TSC1 by IKKb confers tumor angiogenesis through the mTOR pathway. Cell, 130, 440-455. SCI (IF: 32.406)
  58. Y. L. Huang, W. C. Hung, C. C. Lai, Y. H. Liu, S. M. Peng, S. H. Chiu*, 2007, Using Acetate Anions To Induce Translational Isomerization in a Neutral Urea-Based Molecular Switch. Angew. Chem. Int. Ed. Engl., 46, 6629-6633. SCI (IF: 12.73)
  59. S. Y. Hsueh, C. C. Lai,, Y. H. Liu, S. M. Peng, S. H. Chiu, 2007, Highly Selective Na(+)-Templated Formation of [2]Pseudorotaxanes Exhibiting Significant Optical Outputs. Angew. Chem. Int. Ed. Engl. 46, 2013-2017. SCI (IF: 12.73)
  60. C. W. Chiu, C. C. Lai,, S. H. Chiu, 2007, “Threading-Followed-by-Swelling”: A New Protocol for Rotaxane Synthesis. J. Am. Chem. Soc. 129, 3500-3501. SCI (IF: 9.023) (Highlighted in Science Magazine (Editors’ Choice): Science, 2007, 315, 1639)
  61. C. F. Lin, C. C. Lai, Y. H. Liu, S. M. Peng, S. H. Chiu, 2007, Use of Anions to Allow Translational Isomerism of a [2]Rotaxane. Chemistry : a European Journal., 13, 4350-4355. SCI (IF: 5.476)
  62. H. J. Lin, C. C. Lai,, P. D. Chao Lee, S. S. Fan, Y. Tsai, S. Y. Huang, L. Wan, F. J. Tsai, 2007, Aloe-emodin metabolites protected N-methyl-d-aspartate-treated retinal ganglion cells by cu-zn superoxide dismutase. J. Ocul. Pharmacol. Ther. 23, 152-171. SCI (IF: 1.609)
  63. S. Y. Hsueh, C. C. Lai, Y. H. Liu, Y. Wang, S. M. Peng, S. H. Chiu, 2007, Protecting a squaraine near-IR dye through its incorporation in a slippage-derived [2]rotaxane. Org. Lett., 9, 4523-4526. SCI (IF: 5.25)
  64. W. D. Lin, C. H. Wang, C. C. Lee, C. C. Lai,, Y. Tsai, F. J. Tsai, 2007, Genetic mutation profile of isovaleric acidemia patients in Taiwan. Molecular Genetics and Metabolism, 90, 134-139. SCI (IF: 3.539)
  65. C. F. Lin, Y. H. Liu, C. C. Lai, S. M. Peng, S. H. Chiu, 2006*, Precise Facial Control in Threading Guests into a Molecular Cage and the Formation of a Turtlelike Supramolecular Complex. Angew. Chem. Int. Ed. Engl. 45, 3176-3181. (IF: 12.73)
  66. K. W. Cheng, C. C. Lai,, P. T. Chiang, S. H. Chiu, 2006, Reading the operation of an acid/base-controllable molecular switch by naked eye. Chem Commun (Camb)., 27, 2854-2856. SCI (IF: 5.787)
  67. C. W. Lin, F. J. Tsai, L. Wan, C. C. Lai,, K. H. Lin, T. H. Hsieh, S. Y. Shiu, J. Y. Li, 2005, Binding interaction of SARS coronavirus 3CL(pro) protease with vacuolar-H(+) ATPase G1 subunit, FEBS Lett., 579, 6089-6094. SCI. (IF: 3.601)
  68. C. W. Lin, F. J. Tsai, C. H. Tsai, C. C. Lai,, L. Wan, T. Y. Ho, C. C. Hsieh, P. D. Lee Chao, 2005, Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds, Antiviral Res, 68, 36-42. (IF: 4.439)
  69. Q. Q. Ding, W. Xia, J. C. Liu, J. Y. Yang, D. F. Lee, J. Xia, G. Bartholomeu, Y. Li, Y. Pan, Z. Li, R. C. Bargou, J. Qin, C. C. Lai,, F. J. Tsai, C. H. Tsai, M. C. Hung. 2005, Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell, 19, 159-170. SCI (IF: 14.194)
  70. F. C. Hsu, T. J. Ho, C. C. Lai,, C. F. Lin, H. P. Chen, 2005, Cloning, sequencing, expression, and single-step purification of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) from Salmonella typhimurium ATCC 19585. Protein Expression and Purification. 42, 178-181. SCI (IF: 1.644)
  71. W. D. Lin, C. H. Wang, C. C. Lai,, C. C. Lee, F. J. Tsai, 2004, Genetic and biochemical study in a patient with glutaric academia type I. J. Formos. Med. Assoc. 103, 549-554. (IF: 1.125)
  72. 賴建成*、蔡輔仁,質譜術於臨床醫學上之應用,科儀新知,2003.,25(1),18 ~ 32。
  73. C. C. Lai,, C. H. Tsai, F. J. Tsai, J. Y. Wu, W. D. Lin and C. C. Lee, 2002, Rapid screening assay of congenital adrenal hyperplasia by measuirng 17 a-hydroxyprogesterone with high performance liquid chromatography/ electrospray ionization tandem mass spectro-metry from dried blood spots. J. Clin. Lab Anal. 16, 20-25. SCI. (IF: 1.031)
  74. C. C. Lai,, C. H. Tsai, F. J. Tsai, C. C. Lee and W. D. Lin, 2002, Monitoring of congenital adrenal hyperplasia by microbore HPLC-electrospray ionization tandem mass spectrometry of dried blood spots, Clin. Chem. 48. 354-356. SCI (IF: 6.886)
  75. C. C. Lai,, G. R. Her, 2002, Analysis of N-glycosylation of Phospholipase A2 from Venom of Individual Bees by Microbore High-Performance Liquid Chromatography-Electrospray Mass Spectrometry Using an Ion Trap Mass Spectrometer. J. Chromatogr B. 766, 243-250. SCI (IF: 2.971)
  76. W. D. Lin, J. Y. Wu, C. C. Lai,, F. J. Tsai, C. H. Tsai, S. P. Lin, D. M. Niu, 2001, A Pilot Study of Neonatal Screening by Electrospray Ionization Tandem Mass Spectrometry in Taiwan, Acta Paediatr. Taiwan. 42, 224-259. (J=1)
  77. C. C. Lai,, C. H. Tsai, F. J. Tsai, C. C. Lee and W. D. Lin, 2001, Rapid monitoring assay of congenital adrenal hyperplasia with microbore high-performance liquid chromatography/electrospray ionization tandem mass spectrometry from dried blood spots, Rapid Commu. Mass Spectrom. 15, 2145-2151. SCI (IF: 2.846)
  78. C. C. Lai,, G. R. Her, 2000, September, Analysis of Glycoforms of Phospholipase A2 from Honeybee Venom by Capillary Electrophoresis/Electrospray Mass Spectrometry, Rapid Commu. Mass Spectrom. 14, 2012-2018. SCI (IF: 2.846)
  79. C. C. Lai,, P. L. Tsai, C. Yu and G. R. Her, 2000, January, Analysis of a Commercial Preparation of Erythromycin Estolates by Mass Spectrometry/Mass Spectrometry and High Performance Liquid Chromatography/Electrospray Ionization-Mass Spectrometry/Mass Spectrometry Using an Ion Trap Mass Spectrometer, Rapid Commu. Mass Spectrom. 14, 468-475. SCI, (IF: 2.846)
  80. C. C. Lai, and G. R. Her, 1998, January, The Research of Thermal Desorption-Gas Chromatography in Industrial Toxic Materials--Dichloroethane, Trichloroethylene, Methyl Isobutyl Ketone and Ethylacetate. 勞委會委託計畫IOSH86-A305, 1-52.
  81. D. D. Ju, C. C. Lai, and G. R. Her, 1997, April, Analysis of gangliosides by capillary zone electrophoresis and capillary zone electrophoresis-electrospray mass spectrometry, J. Chromatogr. A. 779, 195-203. SCI, (IF: 4.194)


研討會與演講

  1. 2013年中國化學會年會發表2篇壁報,國立暨南大學,2013/11/22-24.。


  2. 質譜分析技術在臨床醫學檢測之學術研討會邀請演講,”Simultaneous detection of diagnostic biomarkers of alkaptonuria, ornithine carbamoyltransferase deficiency, and neuroblastoma disease by high-performance liquid chromatography/tandem mass spectrometry”2013/11/1-2. 國立中山大學


  3. 2013年國際人類蛋白體年會(HUPO)發表4篇壁報,日本橫濱,2013/9/15-18。


  4. 2013年第四屆亞太質譜年會發表8篇壁報,台北國際會議中心,2013/7/10-12。


  5. 2013年國立成功大學暑期生物技術課程邀請演講-“定量蛋白質體”,國立成功大學,2013/08/07。


  6. 2013台灣蛋白體學會年會發表3篇壁報,台北醫學大學,2013/5/24-2012/5/25。


  7. 國立中正大學化生系邀請演講,"The application of mass spectrometry to proteomic and metabolomic research”,2013/3/19。


  8. 國立高雄大學應用化學系邀請演講,”The application of mass spectrometry to proteomic and metabolomic research” 2012/12/20。


  9. 2012年中國化學會年會發表5篇壁報,國立成功大學,2012/12/01-02.。


  10. 以MRM-MS技術驗證生物標記講習會邀請演講,“The application of tandem mass spectrometry to newborn screening and urinary nucleosides as potential tumor markers ”, 2012/9/25. 長庚大學。


  11. 2012 年19th International Mass Spectrometry Conference發表7篇壁報,日本京都,2012/09/15-21.。


  12. 2012年第七屆兩岸分析化學研討會邀請演講,“Analysis of Peptides and Phosphopeptides Using Mass Spectrometry with Electron Transfer Dissociation”, 2012/9/04-2012/9/05. 國立台灣大學化學系。


  13. 2012台灣質譜學會秋季專題研討會邀請演講,“Simultaneous determination of components released from dental composite resins in human saliva by liquid chromatography / multiple-stage ion trap mass spectrometry ”, 2012/9/03. 長庚大學。


  14. 2012年國立成功大學暑期生物技術課程邀請演講-“定量蛋白質體”,國立成功大學,2012/08/13。


  15. 第四屆世界華人質譜研討會暨2012年台灣質譜年會發表9篇壁報,國立成功大學,2012/06/28-30。


  16. 2012台灣蛋白體學會年會發表5篇壁報,高雄醫學大學,2012/5/31-2012/6/1。


  17. 第十八屆分析化學技術交流研討會邀請演講,“Analysis of Peptides and Phosphopeptides Using Mass Spectrometry with Nanoparticles and Chip”, 國立中山大學化學系,2012/5/26-27。


  18. 第十八屆分析化學技術交流研討會發表2篇壁報,國立中山大學化學系,2012/5/26-27。


  19. 2012年(60th ASMS Conference) 60屆美國質譜學會國際年會發表壁報3篇 (加拿大溫哥華), 2012/05/20-24.


  20. 2012 Cyclic di-GMP及黑腐病菌基因體國際研討會發表1篇壁報,“Comparative Proteomic Analysis of Virulence Variations in Xanthomonas Campestris pv. Campestris Strain 17, 11 and P20H”,國立中興大學,2012/03/15。


  21. 國立嘉義大學應用化學系邀請演講,” The application of mass spectrometry to proteomic and metabolomic research” 2012/03/14。


  22. 2011中國化學會年會發表2篇壁報,國立清華大學,2011/12/03-04.。


  23. 2011年台灣質譜學會100年度教育訓練課程演講,中部與南部場次。


  24. 2011年第二屆亞太質譜年會2011 Annual Meeting of KSMS & 2nd AOMSC 邀請英文演講, invited oral in English, “Analysis of Peptides and Phosphopeptides Using Mass Spectrometry with Electron Transfer Dissociation”,Busan, South Korea, 2011/8/17-19.


  25. 2011年國立成功大學暑期生物技術課程邀請演講-“定量蛋白質體”,國立成功大學,2011/08/10。


  26. 2011年第8屆台灣質譜年會邀請演講及擔任分項演講主持人, “Analysis of Biomolecules Using Mass Spectrometry with Carbon Nanotube and Chip”, 中央研究院,2011/7/10-12。

  27. 2011年第8屆台灣質譜年會發表文章共8篇壁報,中央研究院,2011/7/10-12。


  28. 2011年(59th ASMS Conference) 59屆美國質譜學會國際年會發表壁報 (美國丹佛), A novel approach for quantitative peptides analysis by selected electron transfer reaction monitoring. 2011/06/03-10.


  29. 2011轉譯醫學國際研討會暨台灣蛋白體年會邀請演講,“Analysis of Peptides and Phosphopeptides Using Mass Spectrometry with Electron Transfer Dissociation”,國立陽明大學,2011/4/27-28。


  30. 2011年轉譯醫學國際研討會暨台灣蛋白體年會發表文章共6篇壁報,國立陽明大學,2011/4/27-28。


  31. 2011 MRM-MS之轉譯醫學應用講習會邀請演講,“The application of tandem mass spectrometry to newborn screening and urinary nucleosides as potential tumor markers”,長庚大學,2011/4/26。

  32. 行政院衛生署食品藥物管理局邀請演講,“The Application of Mass Spectrometry”,2011/4/18。


  33. 國立台灣師範大學化學系邀請演講,” Analysis of Biomolecules Using Mass Spectrometry with ETD, Carbon Nanotube and Chip” 2011/4/18。


  34. 2010年中國化學會年會邀請演講, “Analysis of Biomolecules Using Mass Spectrometry with Electron Transfer Dissociation, Carbon Nanotube and Chip”,國立臺灣大學,2010/12/4-5.


  35. 2010年中國化學會年會發表文章共5篇壁報,國立臺灣大學,2010/12/4-5.

  36. 東海大學化學系邀請演講,"Analysis of Biomolecules Using Mass Spectrometry with Electron Transfer Dissociation, Carbon Nanotube and Chip”,2010/10/19。


  37. 國立中正大學化生系邀請演講,"Analysis of Biomolecules Using Mass Spectrometry with ETD, Carbon Nanotube and Chip”,2010/9/21。


  38. 2010年國立成功大學暑期生物技術課程邀請演講-“定量蛋白質體”,國立成功大學,2010/08/11。


  39. 2010年第7屆台灣質譜年會擔任分項演講主持人及發表文章共9篇壁報,高雄醫學大學,2010/6/27-29。


  40. 應邀擔任弘光科技大學生物科技系學生專題研究海報競賽評審委員,2010/6/4。

  41. 2010年(58th ASMS Conference) 58屆美國質譜學會國際年會發表壁報 (美國Salt Lake City, Utah), A novel approach for quantitative peptides analysis by selected electron transfer reaction monitoring. 2010/5/23-2010/5/27.


  42. 2010年第十六屆分析化學技術交流研討會 (臺灣大學) 邀請演講:A Novel Approach for Quantitative Peptides Analysis by Selected Electron Transfer Reaction Monitoring. 及四名學生口頭報告. 2010/5/15-2010/5/16.


  43. 2010年疾病標誌國際研討會暨台灣蛋白體年會 (長庚大學) 發表文章共4篇壁報. 2010/4/23-2010/4/24.


  44. 國立暨南大學應用化學系邀請演講-“Analysis of Biomolecules Using Electron Transfer Dissociation Technique and Mass Spectrometry”,2010/3/19。


  45. 2010年亞太層析暨質譜年會 (Asian Pacific Conference of Chromatography & Mass Spectrometry 2010) 發表壁報 (香港) , Comparative Proteomic Profiling of the Human Lung Adenocarcinoma Cells (CL1-0) Expressing miRNA-372, 2010/1/13-2010/1/16.

  46. 2009年「質譜技術在定量蛋白體研究的原理與最新發展」研習會邀請演講, ”Multiplexed isobaric tagging及ETD在定量蛋白體的應用”, 國立成功大學總圖書館,2009/12/11-2009/12/13。


  47. 2009年中國化學會年會 (高雄義守大學燕巢分部) 發表文章共2篇壁報, 2009/12/4-2009/12/6.


  48. 淡江大學化學系邀請演講-“Nano-LC/MS/MS for Proteomic Analysis in Cancer and Rice Research”,2009/4/24。


  49. 2nd Annual Protein and Peotide Conference (PepCon-2009) 邀請英文演講及擔任主持人, invited oral in English and session co-chair, “Simultaneous Qualitation and Quantitation of peptides by Liquid Chromatography/Mass Spectrometry with Electron Transfer Dissociation Technology”, Seoul, South Korea, 2009/4/01-2009/4/05.


  50. 2009年(57th ASMS Conference) 57屆美國質譜學會國際年會發表壁報 (美國費城), Analysis of urinary nucleosides as potential tumor markers in human colorectal cancer by LC/MS/MS.

  51. 2009年台灣質譜學會學術研討會暨2009質譜年會發表文章共11篇壁報


  52. 2009年TPS International Proteomics Conference and 5th AOHIPO Workshop發表文章共7篇壁報


  53. 2008年第二屆世界華人質譜研討會暨2008台灣質譜年會發表文章共9篇壁報


  54. 2008年台灣質譜學會97年度教育訓練課程演講,”質譜分析序論”,北部(7/07~7/25) 、 中部(8/11~8/29) 、南部(9/22~10/10)。

  55. 第五屆兩岸分析化學研討會暨第14屆分析技術交流研討會邀請擔任分項演講主持人,高雄醫學大學,2008/5/24-25。


  56. 2008年食品保健與分析研討會邀請演講-“質譜於臨床健康之研究”, 弘光科技大學民生學院食品營養系暨生物產業科技研究所,2008/5/23。


  57. 國立東華大學化學系邀請演講-“Nano-LC-MS/MS for Proteomic Analysis in Cancer and Rice Research”,2008/1/4。


  58. 2007年第一屆國際癌症學術研討會發表壁報,Proteomic analysis of up-regulated proteins in human promonocyte cells expressing severe acute respiratory syndrome coronavirus 3C-like protease (中國醫藥大學)


  59. 2007年第六屆國際新生兒篩檢學會亞太區年會發表壁報,Simultaneous Monitoring Assay of Alkaptonuria, Ornithine Carbamoyl Transferase Deficiency and Neuroblastoma by High Performance Liquid Chromatography/Electrospray Ionization Mass Spectrometry Using an Ion Trap Mass Spectrometer. (Singapore)


  60. 2007年植物蛋白體研討會負責workshop (中興大學舉辦)


  61. 2007年(55th ASMS Conference) 55屆美國質譜學會國際年會發表壁報: Rapid Screening Assay of Trimethylaminuria with Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry in Urine. (Indianapolis, USA)


  62. 賴建成,2007年台灣質譜年會暨國際學術交流研討會邀請workshop:質譜技術在生物指標開發之應用. (成大化學所)


  63. 2007年分析技術交流研討會邀請演講, “The Application of Mass Spectrometry in Clinical Metabolomics”,國立清華大學,2007/5/26-2007/5/27.


  64. 賴建成,2006年台灣蛋白質體學年會邀請演講, “Identification of over-expressed proteins in oral squamous cell carcinoma (OSCC) patients by clinical proteomic analysis”,中央研究院,2006/12/20.


  65. 賴建成,6th Meeting of the International Society for Neonatal Screening (ISNS) 邀請英文演講, invited oral in English, “Rapid Monitoring Assay of Congenital Adrenal Hyperplasia and Peroxisomal disorders with LC/MS/MS and MALDI-TOF”,Tokushima, Japan, 2006/9/17-2006/9/21.


  66. 賴建成,94年度台灣質譜學會教育課程邀請演講:當質譜儀遇上蛋白質--樣品前處理,2005/9/23-2005/10/14.


  67. 賴建成,2005年華人質譜年會邀請演講, “Rapid Monitoring Assay of Peroxisomal Disorders with Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Using Carbon Nanotubes as Matrices”,國立中興大學,2005/6/16-2005/6/17.


  68. 賴建成,The Applications of Mass Spectrometry in Metabolic and Proteomic Studies, 質譜技術研討會,國立中正大學,2005/1/15.


  69. 賴建成,2004年中國化學會年會邀請演講, “The Application of Mass Spectrometry in Clinical Medicine”,國立中興大學化材館國際會議廳,2004/11/20.


  70. 賴建成,2004台灣質譜學會年會邀請演講:Key Technology in Biomedical/Pharmaceutical Applications: Mass Spectrometry. (台灣大學凝態中心),2004/6/15-2004/6/16.


  71. 2003台灣質譜學會年會邀請演講:MS in pharmaceutical/clinical analysis. (台灣大學凝態中心),2003/6/15-2003/6/16.


  72. 賴建成,質譜儀在新生兒篩檢與醫學上的應用,高雄醫學大學醫化系演講,高雄醫學大學醫化系,2003/4/25


  73. 賴建成,LC/MS技術概論及檢測技術,GC/MS及LC/MS在生醫應用技術,行政院國科會精密儀器發展中心,2003/3/26-2003/3/28


  74. 賴建成,質譜儀於新生兒篩檢與醫學上的應用,國立清華大學原子科學系演講,國立清華大學原子科學系,2003/2/26


  75. 賴建成,The application of mass spectrometry (MS) in clinical medicine,台灣遺傳醫學學術研討會, 桃園石門福華飯店,2003/11/15-2003/11/16


  76. 賴建成,Taiwan Human Genetics Society Conference in 2002/10邀請英文演講, invited oral in English, “Rapid Screening Assay of Congenital Adrenal Hyperplasia with Microbore HPLC-Electrospray Ionization/Tandem Mass Spectrometry of Dried Blood Spots.The application of mass spectrometry (MS) in clinical medicine”, 2002.


  77. 賴建成,質譜儀於新生兒篩檢之應用,國立中山大學化學系演講,國立中山大學化學系,2002/3/5


  78. 賴建成,Rapid Screening and Monitoring Assay of Neuroblastoma with Microbore High Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectr,中國化學年會, 台北中國石油大樓,2002/10/25-2002/10/27


  79. 賴建成,質譜儀在新生兒篩檢上的應用,國立中興大學化學系演講,國立中興大學化學系,2002/10/2


  80. 賴建成,Rapid Screening and Monitoring Assay of Congenital Adrenal Hyperplasia with Microbore High Performance Liquid Chromatography/Electrospray Ionization T,中國化學年會, 台南國立成功大學,2001/12/29-2001/12/30


  81. 賴建成,Analysis of Glycoforms of Phospholipase A2 from Honeybee Venom by Capillary Electrophoresis/Electrospray Ionization Mass Spectrometry,美國質譜年會, Long Beach, CA.,2000//


  82. 賴建成,微管柱液相層析/質譜 (m-HPLC/MS) 對單蜂醣蛋白醣型式之微量分析, 中國化學年會,台中靜宜大學,2000//


  83. 賴建成,毛細管電泳/質譜儀於蜂毒中醣蛋白 (Phospholipase A2) 之分析,中國化學會年會,台北,1999//


  84. 賴建成,單蜂蜂毒之微區與微量質譜分析,中國化學會年會,嘉義,1998//


  85. 賴建成,蜂毒之質譜分析,分析化學技術交流研討會,屏東,1997//


  86. 賴建成,高效率液相層析/離子阱質譜儀於神經性藥物flunarizine之分析,中國化學會年會,新竹,1997//

專  利
 

榮  譽
 
  1. 中國化學會傑出青年化學獎章,2012/12.。


  2. 中興大學特聘教授,2012/08~。


  3. 台灣質譜學會青年學者研究獎,2012/06。


  4. 中興大學100年度傑出青年教師獎.


  5. 2011中國化學會年會研究生論文獎第一名 (簡明瑋)。


  6. 2011-受邀擔任期刊ISRN Spectroscopy 之Editorial board.


  7. 中興大學99年度特別貢獻獎.


  8. 中興大學98年度傑出青年教師獎.


  9. 2009中國化學會年會研究生論文獎佳作 (魏碧瑩).


  10. 第六屆台灣質譜學會學術研討會暨2009質譜年會壁報論文獎共三篇 (魏碧瑩、鄭宇翔、李坤頤)


  11. 2008第二屆世界華人質譜研討會暨2008台灣質譜年會壁報論文獎 (賴若馨)


  12. 協助中國醫藥大學附設醫院獲得2002年國家生技醫療品質獎 (社團法人國家生技醫療產業策進會), 協助建立國內首座利用LC/MS/MS進行新生兒篩檢之平台,並於國內外首度開發利用LC/MS/MS篩檢先天性腎上腺增生症(CAH), 2002。


授課課程
 
1. 功能蛋白質體學 (課程與實驗)

2. 生化質譜分析
3. 蛋白質體分析技術
4. 分子生物學
5. 文獻研討 (in English)
6. 專題討論 (博士班in English)
7. 專題討論 (碩士班)