- Loading of PAX3 to Mitotic Chromosomes Is Mediated by Arginine Methylation and Associated with Waardenburg Syndrome.
Wu TF, Yao YL, Lai IL, Lai CC, Lin PL, Yang WM*.
J Biol Chem. 2015 Aug 14;290(33):20556-64.
PAX3 Loads onto Pericentromeric Heterochromatin During S Phase Through PARP1.
Wu TF, Yao YL, Lai IL, Lee TH, Underhill DA, Yang WM.
Anticancer Res. 2014 Sep;34(9):4717-22.
The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases.
Hsieh FS, Chen NT, Yao YL, Wang SY, Chen JJ, Lai CC, Yang WM*.
Biochim Biophys Acta. 2014 Jul;1839(7):579-91. doi: 10.1016/j.bbagrm.2014.05.007. Epub 2014 May 19.
Loss of ZBRK1 Contributes to the Increase of KAP1 and Promotes KAP1-Mediated Metastasis and Invasion in Cervical Cancer.
Lin LF, Li CF, Wang WJ, Yang WM, Wang DD, Chang WC, Lee WH, Wang JM.
PLoS One. 2013 Aug 22;8(8):e73033. doi: 10.1371/journal.pone.0073033.
PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation.
Liang YC, Hsu CY, Yao YL, Yang WM.
Biochem Biophys Res Commun. 2013 Feb 1;431(1):58-64. doi: 10.1016/j.bbrc.2012.12.092. Epub 2013 Jan 3.
FKBPs in chromatin modification and cancer.
Yao YL, Liang YC, Huang HH, and Yang, W. M.*
Curr Opin Pharmacol. 2011 Aug;11(4):301-7. Epub 2011 Apr 12
Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates.
Yao YL, Yang WM.
J Biomed Biotechnol. 2011;2011:146493. Epub 2010 Dec 22.
HDAC10 relieves repression on the melanogenic program by
maintaining the deacetylation status of repressors.
Lai IL, Lin TP, Yao YL, Lin CY, Hsieh MJ, and Yang, W. M.*
J Biol Chem. 2010 Mar 5;285(10):7187-96. Epub 2009 Dec 22.
Sumoylation of LAP1 is involved in the
HDAC4-mediated repression of COX-2 transcription.
Wang WL, Lee YC, Yang, W. M., Chang WC,
Wang JM.
Nucleic Acids Res. 2008, 36(19): 6066-6079.
HDAC1/HDAC3 modulates
PPARG2 transcription through the sumoylated
CEBPD in hepatic lipogenesis.
Lai PH, Wang WL, Ko CY, Lee YC, Yang,
W. M., Shen TW, Chang WC, Wang JM.
Biochim Biophys Acta. 2008, 1783(10):
1803-1814.
Transcriptional and
subcellular regulation of the TRIP-Br
family.Lai, I. J.,
Wang, S. Y., Yao, Y. L. and Yang, W. M.*Gene.
2007, 388 (1-2): 102-109.
Transcriptional repression
activity of PAX3 is modulated by competition
between corepressor KAP1 and heterochromatin
protein 1. Hsieh,
M. J., Yao, Y. L., Lai, I. L., and Yang,
W. M. *
Biochem Biophys Res Commun. 2006, 349(2):
573-581.
Nuclear proteins: promising
targets for cancer drugs.
Yao Y. L. and Yang W. M.
Curr Cancer Drug Targets. 2005, 5(8):
595-610. (Impact factor: 5.67 for year
2007)
The transcriptional
factor YY1 upregulates the novel invasion
suppressor HLJ1 expression and inhibits
cancer cell invasion.Wang CC, Tsai MF,
Hong TM, Chang GC, Chen CY, Yang WM, Chen
JJ, Yang PC.
Oncogene 2005, 24(25): 4081-4093.
Histone deacetylases:
purification of the enzymes, substrates,
and assayconditions.Rezai-Zadeh
N, Tsai SC, Wen YD, Yao YL, Yang WM, Seto
EMethods Enzymol
2004, 377:167-79
The metastasis-associated
proteins 1 and 2 form distinct protein
complexes with histone deacetylase activity.Yao
YL, Yang WMJ Biol Chem 2003 Oct 24, 278:42560-8.
(Selected as Breaking News pubished in
Leaddiscovery)
Functional domains
of histone deacetylase-3.Yang WM, Tsai
SC, Wen YD, Fejer G, Seto EJ Biol Chem
2002, 277 :9447-9454.
NAPP2, a Peroxisomal
Membrane Protein, Is Also a Transcriptional
Corepressor.Gavva NR, Wen SC, Daftari
P, Moniwa M, Yang WM , Yang-Feng LP, Seto
E, Davie JR, Shen CKGenomics 2002, 79:423-31
Yin-Yang 1 activates
interleukin-4 gene expression in T cells.Guo
J, Casolaro V, Seto E, Yang WM, Chang
C, Seminario MC, Keen J, Georas SNJ Biol
Chem 2001, 276:48871-8
Histone deacetylase
activity represses gamma interferon-inducible
HLA-DR gene expression following the establishment
of a DNase I-hypersensitive chromatin
conformation.Osborne A, Zhang H, Yang
WM, Seto E, Blanck GMol Cell Biol 2001,
21:6495-506
The FK506-binding
protein 25 functionally associates with
histone deacetylases and with transcription
factor YY1.Yang WM, Yao YL, Seto EEMBO
J 2001, 20:4814-25
Regulation of transcription
factor YY1 by acetylation and deacetylation.Yao
YL, Yang WM, Seto E
Mol Cell Biol 2001, 21:5979-91
The growth suppressor
PML represses transcription by functionally
and physically interacting with histone
deacetylases.Wu WS, Vallian S, Seto E,
Yang WM, Edmondson D, Roth S, Chang KSMol
Cell Biol 2001, 21:2259-68
Histone deacetylase
interacts directly with DNA topoisomerase
II.Tsai SC, Valkov N, Yang WM, Gump J,
Sullivan D, Seto ENat Genet 2000, 26:349-53
The histone deacetylase-3
complex contains nuclear receptor corepressors.Wen
YD, Perissi V, Staszewski LM, Yang WM,
Krones A, Glass CK, Rosenfeld MG, Seto
EProc Natl Acad Sci U S A 2000, 97:7202-7
Histone deacetylases
specifically down-regulate p53-dependent
gene activation.Juan LJ, Shia WJ, Chen
MH, Yang WM, Seto E, Lin YS, Wu CWJ Biol
Chem 2000, 275:20436-43
Ligand-induced recruitment
of a histone deacetylase in the negative-feedback
regulation of the thyrotropin beta gene.Sasaki
S, Lesoon-Wood LA, Dey A, Kuwata T, Weintraub
BD, Humphrey G, Yang WM, Seto E, Yen PM,
Howard BH, Ozato KEMBO J 1999, 18:5389-98
RBP1 recruits both
histone deacetylase-dependent and -independent
repression activities to retinoblastoma
family proteins.Lai A, Lee JM, Yang WM,
DeCaprio JA, Kaelin WG, Seto E, Branton
PE
Mol Cell Biol 1999, 19:6632-41
Cloning and characterization
of the mouse histone deacetylase-2 gene.Zeng
Y, Tang CM, Yao YL, Yang WM, Seto EJ Biol
Chem 1998, 273:28921-30
Isolation and characterization
of cDNAs corresponding to an additional
member of the human histone deacetylase
gene family.Yang WM, Yao YL, Sun JM, Davie
JR, Seto EJ Biol Chem 1997, 272:28001-7
The hepatitis B virus
X-associated protein, XAP3, is a protein
kinase C-binding protein.Cong YS, Yao
YL, Yang WM, Kuzhandaivelu N, Seto EJ
Biol Chem 1997, 272:16482-9
Differential effects
of nuclear receptor corepressor (N-CoR)
expression levels on retinoic acid receptor-mediated
repression support the existence of dynamically
regulated corepressor complexes.Soderstrom
M, Vo A, Heinzel T, Lavinsky RM, Yang
WM, Seto E, Peterson DA, Rosenfeld MG,
Glass CK Mol Endocrinol 1997, 11:682-92
Histone deacetylases
associated with the mSin3 corepressor
mediate mad transcriptional repression.
Laherty CD, Yang WM, Sun JM, Davie JR,
Seto E, Eisenman RN Cell 1997, 89:349-56
A complex containing
N-CoR, mSin3 and histone deacetylase mediates
transcriptional repression.
Heinzel T, Lavinsky RM, Mullen TM, Soderstrom
M, Laherty CD, Torchia J, Yang WM, Brard
G, Ngo SD, Davie JR, Seto E, Eisenman
RN, Rose DW, Glass CK, Rosenfeld MGNature
1997, 387:43-8
XAP2, a novel hepatitis
B virus X-associated protein that inhibits
X transactivation.Kuzhandaivelu N, Cong
YS, Inouye C, Yang WM, Seto ENucleic Acids
Res 1996, 24:4741-50
Transcriptional repression
by YY1 is mediated by interaction with
a mammalian homolog of the yeast global
regulator RPD3.Yang WM, Inouye C, Zeng
Y, Bearss D, Seto EProc Natl Acad Sci
U S A 1996, 93:12845-50
Cyclophilin A and
FKBP12 interact with YY1 and alter its
transcriptional activity.Yang WM, Inouye
CJ, Seto EJ Biol Chem 1995, 270:15187-93
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