羅順原

Shun-Yuan Luo

有機化學

Organic Chemistry

B. S., National Tsing Hua University (1995.9 - 1998.6)

M. S., National Tsing Hua University (1998.9 - 2000.6)

Ph. D., National Tsing Hua University (2003.9 - 2008.3)

Postdoctoral Fellow, IBC, Academia Sinica, Taipei, Taiwan

(2008.4 - 2010.1)

Assistant Professor, National Chung Hsing University (2010.2 – 2015.7)

Associate Professor, National Chung Hsing University (2015.8 - present)

 

e-mail: syluo@dragon.nchu.edu.tw

 

醣類、醣脂質與小型分子藥物的合成

我們實驗室將致力於合成醣類、醣脂質及小型分子藥物的新策略開發與研究。我們也應用
一鍋化保護、一鍋化保護
-醣鏈結及一鍋化醣鏈結-去保護等方法來製備出具有生物活性的
生物分子,如
a-galactosyl ceramide 1ganglioside Hp-s1 2natural cerebroside 3等等,並製
備其衍生物以尋找具有活性的先導藥物。

 

Synthesis of carbohydrates, glycolipids and small drug molecules

Our group research focused on the development of novel methodologies involving synthesis of
biological active oligosaccharides, glycolipids, and small drug molecules. Mainly focused on
developing one-pot strategy for protection as well as glycosylation to prepare biological active
molecules of glycolipids such as
a-galactosyl ceramide 1, ganglioside Hp-s1 2, natural
cerebroside 3, and their derivatives for screening bio-active as new lead compounds.

 

Sawant, R. C.; Liao, Y.-J.; Lin, Y.-J.; Badsara, S. S.; Luo, S.-Y.* “Formal synthesis of a
disaccharide repeating unit (IdoAGlcN) of heparin and heparan sulfate”, RSC Adv. 2015,
5, 19027-19033.
(IF2014 = 3.840).

Kuo, T.-M.; Luo, S.-Y.; Chiang, S.-L.; Yeh, K.-T.; Hsu, H.-T.; Wu, C.-T.; Lu, C.-Y.; Tsai, M.-H.;
Chang, J.-G.; Ko, Y.-C.* “Fibrotic Effects of Arecoline N
Oxide in Oral Potentially Malignant Disorders”,
J. Agric. Food Chem. 2015, 63, 5787
5794. (IF2014 = 2.912).

Chen, W.-S.; Sawant, R. C.; Yang, S.-A.; Liao, Y.-J.; Liao, J.-W.; Badsara, S. S.; Luo, S.-Y.*
“Synthesis of Ganglioside Hp-s1”, RSC Adv. 2014, 4, 47752–47761. (IF2014 = 3.840).

Hung, J.-T.; Sawant, R. C.; Chen, J.-C.; Yen, Y.-F.; Chen, W.-S.; Yu, A. L.*; Luo, S.-Y.* “Design
and Synthesis of Galactose-6-OH-modified alpha-Galactosyl Ceramide Analogues with Th2-biased
Immune Responses”, RSC Adv. 2014, 4, 47341–47356. (IF2014 = 3.840).

Sawant, R. C.; Lih, Y.-H.; Yang, S.-A.; Yeh, C.-H.; Tai, H.-J.; Huang, C.-L.; Lin, H.-S.; Badsara, S. S.;
Luo, S.-Y.* “An Unusual Wittig Reaction with Sugar Derivatives: Exclusive Formation of a 4-deoxy
Analogue of alpha-Galactosyl Ceramide”, RSC Adv. 2014, 4, 26524–26534. (IF2014 = 3.840).

Kuo, T.-M.; Luo, S.-Y.; Chiang, S.-L.; Lee, C.-P.; Liu, Y.-F.; Chang, J.-G.; Tsai, M.-H.; Ko*, Y.-C.
Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli
TM4 cells”, J. Biomed. Sci. 2014, 21(93), 1-10. (IF2014 = 2.763, open acess).

Sawant, R. C.; Hung, J.-T.; Chuang, H.-L.; Lin, H.-S.; Chen, W.-S.; Yu, A. L.*; Luo S.-Y.* “Synthesis
of Hydroxylated Analogues of alpha-Galactosyl Ceramide (KRN7000) with Varying Stereochemistry”,
Eur. J. Org. Chem. 2013, 7611–7623. (IF2014 = 3.065).

Chuang, H.-L.; Sawant, R. C.; Luo, S.-Y.* “Unexpected Cyclization During the Mitsunobu Reaction
of
D-Talose ­Derivatives”, Synlett 2013, 24, 522–526. (IF2014 = 2.419).

Yen, Y.-F.; Sawant, R. C.; Luo, S.-Y.* “Concise Syntheses of alpha-Galactosyl Ceramide,
D-ribo-Phytosphingosine and Ceramide”, Synthesis 2013, 45, 511–517.
(IF2014 = 2.689).

Chuang, H.-L.; Sawant, R. C.; Luo, S.-Y.*Yen, Y.-F.; Kulkarni, S. S.; Chang, C.-W.; Luo, S.-Y.*Concise synthesis of alpha-galactosyl ceramide
from
D-galactosyl iodide and D-lyxose”, Carbohydr.
Res. 2013, 368, 35–39. (IF2014 = 1.929).

Boss

羅順原博士

(Dr. Shun-Yuan Luo)

 

 

Ph. D. Students

大頭照

(Yi-Jyun Lin)

博士班三年級

迦納辛(Ganesh Shelke)

博士班二年級

Sankar Arumugam

博士班一年級

Master Students

梁致武 (Zhi-Wu Liang)

碩士班二年級

林秋雅 (Chiu-Ya Lin)

碩士班二年級

陳柏蓉 (Bo-Rong Chen)

碩士班二年級

姜品瑜 (Pin-Yu Jiang)

碩士班二年級

李梓源 (Tzu-Yuan Lee)

碩士班二年級

張永龍 (Yong-Long Chang)

碩士班一年級

陳逸政 (I-Cheng Chen)

碩士班一年級

 

 

 

Graduated Students

2013碩士畢業

莊惠琳

(Huei-Lin Chuang)

生達化學製藥

2013碩士畢業

顏郁芬

(Yu-Fen Yen)

農委會

2013碩士畢業

林華軒

(Huan-Shuan Lin)

台灣尖端先進生技醫藥

2013碩士畢業

張峻瑋

(Chun-Wei Chang)

中研院化學所

2013碩士畢業

陳吉川

(Ji-Chuan Chen)

興農股份有限公司

2014碩士畢業

陳宛欣

(Wan-Shin Chen)

輝瑞生技新豐廠

2014碩士畢業

黃崇理

(Chung-Li Huang)

 

2014休學

廖容瑋

(Jung-Wei Liao)

台灣糖業股份有限公司

2014碩士畢業

(Yu-Hsuan Lih)

中研院基因體中心

2014碩士畢業

廖盈茹

(Ying-Ju Liao)

力晶科技

2015博士畢業

抽土

(R. C. Sawant)

清華大學化學所

2015碩士畢業

葉俊鴻

(Chun-Hong Yeh)

中研院化學所

2015碩士畢業

戴弘儒

 (Hung-Ju Tai)

服役

2015碩士畢業

楊世安

(Shih-An Yang)

國衛院

 

 


 


 

e-mail: syluo@dragon.nchu.edu.tw

 

lab phone: 04-2284-0411 ext 815

 

cell phone: 0928-502-344

 

歡迎有志從事藥物開發的碩士生、博士生與博士後研究員儘速與本人連絡。
在研究的過程中難免會遇到困難與瓶頸,但是實驗室成員們相處融洽,也與指導
老師的互動良好。已畢業的學生們都可以找到很好的工作,例如農藥廠、原料藥
廠、藥廠及生技公司的研發人員。