cfalee@dragon.nchu.edu.tw

有機化學／催化反應

Organic Chemistry / Catalysis

1. B. S., Tam-Kang University (1997)

2. Ph. D., National Taiwan University (2002)

3. Postdoactoral Researcher, Academia Sinica, Taipei, Taiwan (2002-2003)

4. Postdoctoral Associate, Yale University (2003-2004)

5. Postdoctoral Fellow, University of Edinburgh (2005-2007)

6. Assistant Professor, National Chung Hsing University (2008-2011)

7. Associate Professor, National Chung Hsing University (2011-present)

超分子化學在催化上的應用是最近相當熱門的研究領域。本實驗室的研究興趣是利用非共價鍵的策略建立具有催化活性的分子，因為催化中心的疏水作用，在常見的化學反應中以水替代有機溶劑是我們研究的方向。更重要的是利用非共價鍵的方式，可以方便的引進手性中心而形成不對稱的奈米級反應器，這將應用在不對稱催化反應。另外，開發新的配體並探討其結構對於有機金屬催化反應的影響；以及新型態的分子開關在有機材料上的應用也是我們很感興趣的課題。

Supramolecular catalysis is a very hot topic in recent years. Our research is focused on constructing a reactive center for catalysis through non-covalent approaches. The hydrophobic character of such reactive centers should make it possible to perform common chemical reactions using water as a solvent. More importantly, the non-covalent approach makes it very convenient to introduce a chiral environment to such 'nano-reactors'. It would ultimately be interesting to utilize these 'nano-reactors' in the area of asymmetric catalysis “on water”. In combination with the development of new ligands for catalysis and the design of molecular switches, these projects make up the core of our research interests.

1. Kao, H.-L.; Chen, C.-K.; Wang, Y.-J.; Lee, C.-F.* An Efficient Copper-Catalyzed Cross-Coupling Reaction of Thiols with Aryl Iodides. Eur. J. Org. Chem., 2011, 1776-1781.

2. Ballesteros, B.; Faust, T. B.; Lee, C.-F.; Leigh, D. A.*; Muryn, C. A.; Pritchard, R. G.; Schultz, D.; Teat, S. J.; Timco, G. A.; Winpenny, R. E. P.* Synthesis, Structure, and Dynamic Properties of Hybrid Organic-Inorganic Rotaxanes. J. Am. Chem. Soc., 2010, 132, 15435-15444.

3. Lin, C.-H.; Wang, Y.-J.; Lee, C.-F.* Efficient Copper-Catalyzed Cross-Coupling Reaction of Alkynes with Aryl Iodides. Eur. J. Org. Chem., 2010, 4368-4371.

4. Chen, C.-K.; Chen, Y.-W.; Lin, C.-H.; Lin, H.-P.*; Lee, C.-F.* Synthesis of CuO on mesoporous silica and its applications for coupling reactions of thiols with aryl iodides. Chem. Commun., 2010, 46, 282-284.

5. Wu, J.-R.; Lin, C.-H.; Lee, C.-F.* Iron-catalyzed thioetherification of thiols with aryl iodides. Chem. Commun., 2009, 4450-4452.

6. Lee, C.-F.; Leigh, D. A.*; Pritchard, R. G.; Schultz, D.; Teat, S. J.; Timco, G. A.; Winpenny, R. E. P.* Hybrid Organic-Inorganic Rotaxanes and Molecular Shuttles. Nature, 2009, 458, 314-318.

7. Serreli, V.; Lee, C.-F.; Kay, E. R.; Leigh, D. A.* A Molecular Information Ratchet. Nature, 2007, 445, 523-527.

8. Huang, L.-F.; Lee, C.-F.; Tseng, J.-C.; Luh, T.-Y.* A Convenient Synthesis of Propargylic Dithioacetals. Synlett, 2006, 3173-3175.

9. Luh, T.-Y.*; Lee, C.-F. Dithioacetals as Zwitterion Synthons. Eur. J. Org. Chem., 2005, 3875-3885. (invited review, cover picture)

10. Zhang, L.-Z.; Chen, C.-W.; Lee, C.-F.; Wu, C.-C.*; Luh, T.-Y.* Non-amine-based furan-containing oligoaryls as efficient hole transporting materials. U.S.Patent 60/404,090 (filed August 16, 2002).

11. Lee, C.-F.; Liu, C.-Y.; Song, H.-C.; Luo, S.-J.; Tseng, J.-C.; Tso, H.-H.; Luh, T.-Y.* Bidirectional iterative synthesis of alternating benzene furan oligomers towards molecular wires. Chem. Commun., 2002, 2824-2825.

12. Zhang, L.-Z.; Chen, C.-W.; Lee, C.-F.; Wu, C.-C.*; Luh, T.-Y.* Non-amine-based Furan-containing Oligoaryls as Efficient Transporting Materials. Chem. Commun., 2002, 2336-2337.

13. Lee, C.-F.; Yang, L.-M.; Hwu, T.-Y.; Feng, A.-S.; Tseng, J.-C.; Luh, T.-Y.* One-Pot Synthesis of Substituted Furans and Pyrroles from Propargylic Dithioacetals. New Annulation Route to Highly Photoluminescent Oligoaryls. J. Am. Chem. Soc., 2000, 122, 4992-4993.

Conference Papers:

1. “Recent Developments In The Transition Metal Catalyzed C-S and C-O Bonds Cross-Coupling Reactions” Lee, C.-F. Oral presentation at Taipei: International Symposium for Chinese Organic Chemists, October 22-25, 2010.

2. “Synthesis of CuO on Mesoporous Silica and its Applications for Coupling Reactions of C-S and C-O Bonds” Lee, C.-F. Oral presentation at Taipei: 24^th International Conference on Organometallic Chemistry, July 18-23, 2010.

3. “Transition-Metal-Catalyzed Thioetherification of Thiois with Aryl Iodides” Lee, C.-F. Oral presentation at Singapore: Inaugural (1st) International Conference on Molecular & Functional Catalysis (ICMFC-1), July 11-15, 2010.

國立中興大學化學系National Chung Hsing University Department of Chemistry

地址:台中市國光路250號 化學館 電話:04-22840411 傳真:04-22862547